The Effect of Intercellular Adhesion Molecule- 1 Gene Polymorphism on Atherosclerosis in Patients with Glycogen Storage Disease Type 1

Aim: Glycogen storage disease type 1 is characterized with hypertriglyceridemia which does not lead to atherosclerosis. The human intercellular adhesion molecule-1 gene has been shown to be affected in atherosclerosis and postprandial hypertriglyceridemia. Materials and Methods: In the present paper, the authors genotyped the Glu241Arg polymorphism in the intercellular adhesion molecule-1 gene in 35 patients with Glycogen storage disease type 1 and 108 healthy controls. Results: The results indicated a significant decrease in the frequency of the GG genotype in Glycogen storage disease type I patients compared to healthy controls. In addition, a significant correlation between the GG genotype and triglyceride levels was seen in Glycogen storage disease type 1 patients. Conclusion: It is thus concluded that the GG genotype could protect Glycogen storage disease type I patients from the development of atherosclerosis.