Investigation of in vitro efficiency of magnetic nanoparticle-conjugated I-125-uracil glucuronides in adenocarcinoma cells

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dc.contributor.authorMedine, E. Ilker
dc.contributor.authorUnak, Perihan
dc.contributor.authorSakarya, Serhan
dc.contributor.authorOzkaya, Feriha
dc.date.accessioned2019-10-27T21:35:57Z
dc.date.available2019-10-27T21:35:57Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractModification of the magnetic properties of a drug can be used to direct the drug to the desired site, enhancing its therapeutic effectiveness and reducing side effects. In this study, surface-modified magnetic nanoparticles were immobilized with uracil glucuronide derivatives and then labeled with I-125. The morphology, structure, and composition of the magnetic particles were examined by TEM, SEM, VSM, and XRD. The particles sizes were about 50 nm. The labeling yield was 93.8% for uracil-O-glucuronide-immobilized magnetic particles and 95.0% for uracil-N-glucuronide-immobilized magnetic particles. The cell incorporation rates of N- and O-glucuronides were higher than those of uracil. The incorporation rates of uracil-, O-glucuronide-, and N-glucuronide-conjugated magnetic particles were all high. The cell incorporation rates of ligand-conjugated magnetic particles increased under a magnetic field.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [105 S 486]; Ege UniversityEge University [06 NBE 03, 07 ILAM 01]en_US
dc.description.sponsorshipThis work has been financially supported by TUBITAK (contract no 105 S 486), Ege University Research Fund (contact no 06 NBE 03), and Ege University Research Fund (contact no 07 ILAM 01). The authors thank Adnan Menderes University Science Technology Research and Application Centre for conducting the cell culture experiments.en_US
dc.identifier.doi10.1007/s11051-011-0436-6
dc.identifier.endpage4715en_US
dc.identifier.issn1388-0764
dc.identifier.issn1572-896X
dc.identifier.issn1388-0764en_US
dc.identifier.issn1572-896Xen_US
dc.identifier.issue10en_US
dc.identifier.startpage4703en_US
dc.identifier.urihttps://doi.org/10.1007/s11051-011-0436-6
dc.identifier.urihttps://hdl.handle.net/11454/45965
dc.identifier.volume13en_US
dc.identifier.wosWOS:000295609700029en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Nanoparticle Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectUracilen_US
dc.subjectGlucuronideen_US
dc.subjectIodineen_US
dc.subjectCell cultureen_US
dc.subjectDrug deliveryen_US
dc.subjectNanomedicineen_US
dc.titleInvestigation of in vitro efficiency of magnetic nanoparticle-conjugated I-125-uracil glucuronides in adenocarcinoma cellsen_US
dc.typeArticleen_US

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