Effect of rosemary (Rosmarinus officinalis) extract on the biodistribution of 99mTc sulphur colloid and on the radiolabeled blood constituents

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dc.contributor.authorUçar E.
dc.contributor.authorTeksöz S.
dc.contributor.authorIçhedef C.
dc.contributor.authorKilçar A.Y.
dc.contributor.authorÜnak P.
dc.date.accessioned2019-10-27T08:24:09Z
dc.date.available2019-10-27T08:24:09Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractWith this study we evaluated the effects of the herb rosemary (Rosmarinus officinalis L. Lamiaceae) extract on the labeling of blood constituents with technetium-99m (99mTc) labeled sulphur colloid and on the biodistribution of 99mTc-Sulphur Colloid in Wistar albino rats. For this purpose, two groups of animals (male wistar rats, 130-140 g) were treated (1 mL) with a rosemary extract (750 mg/kg body wt.,n=9) and water (control, n=9) separately by gavage for five days. 99mTc-Sulphur Colloid was administrated by intravenous injection; organs/tissues were withdrawn and weighted. Blood was centrifuged, plasma and blood cells were isolated. The radioactivity was counted to calculate the percentage of activity per gram for each organ/tissue and percentage of activity in blood cells and plasma. A signifi cant increase (p<0.05) in the uptake of 99mTc-Sulphur Colloid in the liver after the treatment with rosemary extract was observed. These results indicate that the substances or metabolites of the rosemary extract would change the biodistribution of 99mTc-Sulphur Colloid.en_US
dc.identifier.doi10.1590/S0102-695X2012005000148
dc.identifier.endpage185en_US
dc.identifier.issn0102695X
dc.identifier.issn0102-695Xen_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage182en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-695X2012005000148
dc.identifier.urihttps://hdl.handle.net/11454/26537
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSociedade Brasileira de Farmacognosiaen_US
dc.relation.ispartofBrazilian Journal of Pharmacognosyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiodistributionen_US
dc.subjectBlooden_US
dc.subjectRatsen_US
dc.subjectRosmarinus officinalisen_US
dc.subjectTechnetium-99men_US
dc.titleEffect of rosemary (Rosmarinus officinalis) extract on the biodistribution of 99mTc sulphur colloid and on the radiolabeled blood constituentsen_US
dc.typeArticleen_US

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