Evaluation of Long Term Respiratory Complications in Childhood and Adolescent Cancer Survivors

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dc.contributor.authorErgin, Firat
dc.contributor.authorCetingul, Nazan
dc.contributor.authorDemir, Esen
dc.contributor.authorSayiner, Abdullah
dc.contributor.authorAlper, Hudaver
dc.contributor.authorGulen, Figen
dc.date.accessioned2024-08-25T18:48:30Z
dc.date.available2024-08-25T18:48:30Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: In addition to increased survival rates, systemic complications which can impair the quality of life have been seen in 25-30% of childhood and adolescent cancer cases. The respiratory system is one of the severely affected systems. We aimed to evaluate late respiratory complications and risk factors in pediatric and adolescent cancers.Materials and Methods: We examined the pulmonary complications of 50 cancer patients and 40 control cases. We asked about environmental exposures, physical examinations performed, and pulmonary function tests (PFT) spirometry, diffusing capacity of the lungs for carbon). X-ray was performed on all patients in the patient group and on patients with indications in the control group.Results: In the patient group, there was impairment of pulmonary function in 52%, [24% small airway disease (SAD)], 14% diffusion disorders (DD) and 14% combined disorders (CD) compared to 22.5% in the control group (p=0.007). There was a higher risk of restrictive disorder and/ or SAD in those cancer patients who were diagnosed prior to 2 years of age. Additionally, there was a higher rate of SAD in those patients with soft tissue sarcomas and a higher rate of restrictive disease in those patients who had received high-dose alkylating agents. No significant PFT impairment was observed in the other patient groups.Conclusion: There is a high incidence of respiratory impairment in childhood and adolescent cancer survivors. They need to be followed up by a multidisciplinary team and be informed about the additional risk factors which may cause lung function loss.en_US
dc.identifier.doi10.4274/jpr.galenos.2022.98216
dc.identifier.endpage18en_US
dc.identifier.issn2147-9445
dc.identifier.issue1en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://doi.org/10.4274/jpr.galenos.2022.98216
dc.identifier.urihttps://hdl.handle.net/11454/102298
dc.identifier.volume10en_US
dc.identifier.wosWOS:000942583000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal of Pediatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectSurvivors of childhood canceren_US
dc.subjectpulmonary injuryen_US
dc.subjectpulmonary function testsen_US
dc.subjectAcute Lymphoblastic-Leukemiaen_US
dc.subjectPulmonary-Functionen_US
dc.subject5-Year Survivorsen_US
dc.subjectLate Mortalityen_US
dc.subjectFollow-Upen_US
dc.subjectChildrenen_US
dc.subjectDiseaseen_US
dc.subjectChemotherapyen_US
dc.subjectRadiotherapyen_US
dc.subjectImpairmenten_US
dc.titleEvaluation of Long Term Respiratory Complications in Childhood and Adolescent Cancer Survivorsen_US
dc.typeArticleen_US

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