Neurotoxic effects of cypermethrin in Wistar rats: A haematological, biochemical and histopathological study

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dc.contributor.authorSayim, F
dc.contributor.authorYavasoglu, NUK
dc.contributor.authorUyanikgil, Y
dc.contributor.authorAktug, H
dc.contributor.authorYavasoglu, A
dc.contributor.authorTurgut, M
dc.date.accessioned2019-10-27T18:57:43Z
dc.date.available2019-10-27T18:57:43Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractCypermethrin is a synthetic pyrethroid that belongs to a group of insecticides with low mammalian toxicity but high insecticidal activity. The present study was undertaken to evaluate subacute toxicity of orally administered cypermethrin in rats based on the haematological, enzymological, and histological brain examination. The study was conducted on 8-week old male Wistar rats and Kra1 250 EC (250 a of cypermethrin/l) was orally administered (60, 150, and 300 mg/kg) for 28 consecutive day. Thus, the investigation covered four groups of animals: three experimental groups and one control group, of 20 rats each. Our results demonstrated that experimental groups receiving both 150 and 300 mg/kg cypermethrin treatment led to significant dose-dependent decrease in some haematological parameters [red blood cell (RBC) counts, haematocrite (Ht), thrombocyte, and mean corpuscular haemoglobin (MCH) values] at the end of the experiment. When compared with control animals, there were significant increases between initial body weights and final body weights of cypermethrin treated rats, but there was a significant decrease in brain/body weight ratio of the animals of all treated groups. Furthermore, there was no statistical difference between control group and all experimental groups for brain acetylcholinesterase (AChE) and blood cholinesterase (ChE) enzyme activities, although brain AChE activities were increased in rats treated with a dose of 150 and 300 mg/kg cypermethrin. Histologically, some deformation areas due to ischemia and pyknosis of the cytoplasm of the neurons were observed in brain tissues of rats treated with all doses of cypermethrin.en_US
dc.identifier.doi10.1248/jhs.51.300
dc.identifier.endpage307en_US
dc.identifier.issn1344-9702
dc.identifier.issn1347-5207
dc.identifier.issn1344-9702en_US
dc.identifier.issn1347-5207en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage300en_US
dc.identifier.urihttps://doi.org/10.1248/jhs.51.300
dc.identifier.urihttps://hdl.handle.net/11454/37363
dc.identifier.volume51en_US
dc.identifier.wosWOS:000229868300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPharmaceutical Soc Japanen_US
dc.relation.ispartofJournal of Health Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcypermethrinen_US
dc.subjecthaematologyen_US
dc.subjectbrainen_US
dc.subjecthistologyen_US
dc.subjectraten_US
dc.titleNeurotoxic effects of cypermethrin in Wistar rats: A haematological, biochemical and histopathological studyen_US
dc.typeArticleen_US

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