Diversity and antibiotic-producing potential of cultivable marine-derived actinomycetes from coastal sediments of Turkey

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dc.contributor.authorOzcan, Kadriye
dc.contributor.authorAksoy, Semiha Cetinel
dc.contributor.authorKalkan, Orcun
dc.contributor.authorUzel, Atac
dc.contributor.authorHames-Kocabas, E. Esin
dc.contributor.authorBedir, Erdal
dc.date.accessioned2019-10-27T22:08:38Z
dc.date.available2019-10-27T22:08:38Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractMarine environments, especially sediments, are rich sources of actinomycetes that provide many bioactive compounds, primarily antibiotics. The goal of this study was to investigate the diversity of cultivable actinomycetes and their potential to produce antibiotics from sediments collected from the coastal zones of Turkey. Thirty sediment samples were collected from nine different coastal sites in three seas surrounding the Anatolian Peninsula of Turkey. Of the samples, 6 were collected from one site in the Black Sea, 18 from seven sites in the Aegean Sea, and 6 from one site in the Mediterranean Sea. Strains of pure actinomycetes were isolated by modified actinomycetes isolation agar (MAIA), M1 agar, M6 agar, and modified R2A agar. Ethyl acetate extracts and fermentation broths were used for the evaluation of antimicrobial activity against antibiotic resistant test microorganisms. The identification of the isolates was undertaken by 16S rRNA gene sequencing. A total of 261 strains of actinomycetes were isolated, of which 66 (25 %) were active against at least one antibiotic-resistant microorganism. Sixty-five of the actinomycetes isolates with antimicrobial activity were Streptomyces spp. and one was Nocardia sp., which implied that genus Streptomyces was predominant. Whereas MAIA agar was the best medium to recover actinomycetes, M6 agar was superior to others for the isolation of antibiotic-producing strains. Extensive screening of the extracts from the 261 isolates for antimicrobial activities revealed considerable potential to produce antibiotics. These findings imply that actinomycetes from marine sediments of the Anatolian Peninsula coasts have potential for the discovery of novel bioactive compounds.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-109S361]; Ege University Research FoundationEge University [2009 Fen 061]en_US
dc.description.sponsorshipThis study was supported financially by the Scientific and Technological Research Council of Turkey (TUBITAK, SBAG-109S361) and Ege University Research Foundation (2009 Fen 061). We would also like to thank Associate Professor Ikbal Agah Ince for his valuable help with the sequences and M. Baki Yokes for providing the sediment samples.en_US
dc.identifier.doi10.1007/s11368-013-0734-y
dc.identifier.endpage1501en_US
dc.identifier.issn1439-0108
dc.identifier.issn1439-0108en_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1493en_US
dc.identifier.urihttps://doi.org/10.1007/s11368-013-0734-y
dc.identifier.urihttps://hdl.handle.net/11454/49211
dc.identifier.volume13en_US
dc.identifier.wosWOS:000323251600017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofJournal of Soils and Sedimentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnatolian Peninsulaen_US
dc.subjectAntimicrobial activityen_US
dc.subjectBiodiversityen_US
dc.subjectCoastal marine sedimentsen_US
dc.subjectMarine derived actinomycetesen_US
dc.titleDiversity and antibiotic-producing potential of cultivable marine-derived actinomycetes from coastal sediments of Turkeyen_US
dc.typeArticleen_US

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