Design, synthesis and evaluation of the biological activities of some new carbohydrazide and urea derivatives [Bazı yeni karbohidrazit ve üre türevlerinin tasarımı, sentezi ve biyolojik aktivitelerinin değerlendirilmesi]

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dc.contributor.authorTok F.
dc.contributor.authorİlhan R.
dc.contributor.authorGünal S.
dc.contributor.authorBallar-Kirmizibayrak P.
dc.contributor.authorKoçyiğit-Kaymakçioğlu B.
dc.date.accessioned2019-10-27T08:01:37Z
dc.date.available2019-10-27T08:01:37Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: Urea and carbohydrazide derivatives are important compounds exhibiting cytotoxic activities. In this study, a series of new urea and carbohydrazide derivatives containing an pyridine ring were synthesized and evaluated for cytotoxic activity. Materials and Methods: The proposed structures of the synthesized compounds were confirmed using elemental analysis, IR, and 1 H-NMR spectroscopic techniques. The cytotoxic potencies of synthesized compounds were determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT) on BRCA mutant-carrying HCC1937 and Capan-1 cell lines, as well as on MCF7, HeLa, and MRC5 cells. Results: 3a, 3b, 3c and 3d showed cytotoxic activity against all cancer cell lines. Conclusion: Our data indicate that compounds 3a-d are more selective to cancer cells compared with nontumoral fibroblasts; however, these compounds are not more potent on HR defective cells with BRCA mutants. © Turk J Pharm Sci, Published by Galenos Publishing House.en_US
dc.identifier.doi10.4274/tjps.64935
dc.identifier.endpage308en_US
dc.identifier.issn1304530X
dc.identifier.issn1304-530Xen_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://doi.org/10.4274/tjps.64935
dc.identifier.urihttps://hdl.handle.net/11454/25031
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Pharmacists Associationen_US
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbohydrazideen_US
dc.subjectCytotoxic activityen_US
dc.subjectUreaen_US
dc.titleDesign, synthesis and evaluation of the biological activities of some new carbohydrazide and urea derivatives [Bazı yeni karbohidrazit ve üre türevlerinin tasarımı, sentezi ve biyolojik aktivitelerinin değerlendirilmesi]en_US
dc.typeArticleen_US

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