Ophthalmic applications of SLN and NLC

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dc.contributor.authorOkur N.Ü.
dc.contributor.authorGökçe E.H.
dc.date.accessioned2019-10-26T21:17:27Z
dc.date.available2019-10-26T21:17:27Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The eyes are among the most readily accessible organs in terms of location in the body, yet drug delivery to eye tissues is particularly problematic. The anatomy, physiology and biochemistry of the eye limit the ophthalmic delivery of drugs. Numerous strategies in ophthalmic drug delivery have been made to expand the bioavailability and to prolong the remaining time of drugs treated topically to eye. Methods: Designing a novel delivery vehicles that can proficiently target the diseased eye tissue, generate high drug levels, and keep sustained and effective concentrations with no or minimum side effects is the main concentration of present examination. One of the encouraging approaches currently is the use of lipidic nanoparticle vehicles categorized by a submicron-meter dimension. Due to their properties and numerous advantages, solid lipid nanoparticles and nanostructure lipid carriers are promising systems for ocular drug delivery. Conclusion: The focus of this review is on the recent developments in ophthalmic lipid nanoparticles, the rationale for their use, drug loaded SLNs and NLCs, and the characteristic advantages, limitations of this system and recent studies. © 2017 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1381612823666171115113101
dc.identifier.endpage6683en_US
dc.identifier.issn1381-6128
dc.identifier.issn1381-6128en_US
dc.identifier.issue43en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6676en_US
dc.identifier.urihttps://doi.org/10.2174/1381612823666171115113101
dc.identifier.urihttps://hdl.handle.net/11454/16372
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofCurrent Pharmaceutical Designen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLipid nanoparticlesen_US
dc.subjectNanocarriersen_US
dc.subjectNanotechnologyen_US
dc.subjectNLCen_US
dc.subjectOcular drug deliveryen_US
dc.subjectSLNen_US
dc.titleOphthalmic applications of SLN and NLCen_US
dc.typeReview Articleen_US

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