Chemical composition and biological activities of Cypriot propolis

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dc.authoridDemirci, Betul/0000-0003-2343-746X
dc.authoridKirci, Damla/0000-0002-3479-3999
dc.authoridOzverel, Cenk Serhan/0000-0001-9932-4774
dc.authorscopusid35100694300
dc.authorscopusid36091846900
dc.authorscopusid57207250833
dc.authorscopusid57286529500
dc.authorscopusid57214128114
dc.authorscopusid26648037000
dc.authorscopusid57217988142
dc.authorwosidDemirci, Betul/AHA-2298-2022
dc.authorwosidKirci, Damla/GLR-4714-2022
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorSarikahya, Nazli Boke
dc.contributor.authorOzverel, Cenk Serhan
dc.contributor.authorBarlas, Ayse Bercin
dc.contributor.authorKirci, Damla
dc.contributor.authorAkgun, Ismail Hakki
dc.contributor.authorYalcin, Tansel
dc.date.accessioned2023-01-12T19:58:58Z
dc.date.available2023-01-12T19:58:58Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractPropolis compositions are highly variable, depending on the geographic region and the season of collection. In this study, propolis samples from seven different regions of Cyprus were studied for the first time by means of chemical content and biological activities. Secondary metabolite composition was determined by LC-HRMS. While the major flavonoids found were isosakuranetin, naringenin, rhamnocitrin, diosmetin, chrysin and acacetin, interestingly verbascoside, a phenylethanoid glycoside, and chlorogenic acid were identified as the major compounds in the ethanol-water extracts. alpha-Pinene was detected as the major compound of propolis extracts according to the volatile compositions via GC-MS. Karaoglanoglu and Tirmen extracts, presenting different chemical profiles, exerted enormous cytotoxic activity by MTT assay (IC50: 2.36-11.56 mu g/mL; 1.44-9.33 mu g/mL, respectively). The highest iNOS inhibition potential was detected in the Karpaz extract (IC50:2.6 mu g/mL) in LPS induced RAW 264.7 cells whereas the Guzelyurt sample demonstrated remarkable antioxidant (88.82 +/- 0.10%) and antimicrobial activities (with a MIC value of 31.2 mu g/mL against S. aureus, S. epidermidis, E. faecium, and E. faecalis).en_US
dc.identifier.doi10.1080/00218839.2021.1977028
dc.identifier.endpage245en_US
dc.identifier.issn0021-8839
dc.identifier.issn2078-6913
dc.identifier.issn0021-8839en_US
dc.identifier.issn2078-6913en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85116417655en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage233en_US
dc.identifier.urihttps://doi.org/10.1080/00218839.2021.1977028
dc.identifier.urihttps://hdl.handle.net/11454/77063
dc.identifier.volume61en_US
dc.identifier.wosWOS:000704263800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Apicultural Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPropolisen_US
dc.subjectCyprusen_US
dc.subjectLC-HRMSen_US
dc.subjectGC-MSen_US
dc.subjectbiological activitiesen_US
dc.subjectNitric-Oxideen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectGene-Expressionen_US
dc.subjectEthanol Extracten_US
dc.subjectIn-Vitroen_US
dc.subjectAntioxidanten_US
dc.subjectAntibacterialen_US
dc.subjectInhibitionen_US
dc.subjectAntifungalen_US
dc.subjectFlavonoidsen_US
dc.titleChemical composition and biological activities of Cypriot propolisen_US
dc.typeArticleen_US

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