THE EMBRYOTOXIC AND GENOTOXIC EFFECTS OF WIDELY USED BETA BLOCKERS ON SEA URCHIN (PARACENTROTUS LIVIDUS) EMBRYOS

Küçük Resim Yok

Tarih

2016

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Parlar Scientific Publications (P S P)

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Pharmaceutically active compounds have attracted great attention last decades because of their potential environmental affects. Beside the expected impacts, depends on the concentrations of pharmaceuticals, unexpected side effects also can be occurred. In our study the effects of Atenolol, propranolol, metoprolol and nadolol are being investigated by embryos of sea urchin Paracentrotus lividus which is one of important member of aquatic ecosystems. According to our results the EC50 values of embryotoxicity are 0,232 mg/l for Propranolol; 9,32 mg/l for Metoprolol, 33,802 mg/l for Atenolol and 53,08mg/l for Nadolol. Also we detect some chromosomal abnormality like mitotic bridge and scattered formations. According to the results, we can have concluded that beta blockers have effects on embryonic development of sea urchin and these effects can be seen on embryonic stages, larval development and cytotoxic level.

Açıklama

Anahtar Kelimeler

Beta blockers, sea urchin, embryotoxicity, genotoxicity

Kaynak

Fresenius Environmental Bulletin

WoS Q Değeri

Q4

Scopus Q Değeri

Cilt

25

Sayı

12A

Künye