THE EMBRYOTOXIC AND GENOTOXIC EFFECTS OF WIDELY USED BETA BLOCKERS ON SEA URCHIN (PARACENTROTUS LIVIDUS) EMBRYOS
Küçük Resim Yok
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Parlar Scientific Publications (P S P)
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pharmaceutically active compounds have attracted great attention last decades because of their potential environmental affects. Beside the expected impacts, depends on the concentrations of pharmaceuticals, unexpected side effects also can be occurred. In our study the effects of Atenolol, propranolol, metoprolol and nadolol are being investigated by embryos of sea urchin Paracentrotus lividus which is one of important member of aquatic ecosystems. According to our results the EC50 values of embryotoxicity are 0,232 mg/l for Propranolol; 9,32 mg/l for Metoprolol, 33,802 mg/l for Atenolol and 53,08mg/l for Nadolol. Also we detect some chromosomal abnormality like mitotic bridge and scattered formations. According to the results, we can have concluded that beta blockers have effects on embryonic development of sea urchin and these effects can be seen on embryonic stages, larval development and cytotoxic level.
Açıklama
Anahtar Kelimeler
Beta blockers, sea urchin, embryotoxicity, genotoxicity
Kaynak
Fresenius Environmental Bulletin
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
25
Sayı
12A