Association between the low percentage of forced vital capacity and increased mortality after left ventricular assist device implantation

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dc.contributor.authorEkren, Pervin Korkmaz
dc.contributor.authorOzturk, Pelin
dc.contributor.authorErtugay, Serkan
dc.contributor.authorOzdil, Ali
dc.contributor.authorNalbantgil, Sanem
dc.contributor.authorEngin, Cagatay
dc.contributor.authorOzbaran, Mustafa
dc.date.accessioned2020-12-01T11:57:56Z
dc.date.available2020-12-01T11:57:56Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: This study aims to investigate the effect of low percentage of forced vital capacity measured in the preoperative period on the 28-day mortality in patients undergoing left ventricular assist device implantation. Methods: A total of 131 patients (111 males, 20 females; median age 54 years; range, 47 to 59 years) who underwent left ventricular assist device implantation with HeartWare (TM) between December 2010 and January 2016 were retrospectively analyzed. the patients were divided into two groups according to the results of pulmonary function test as a forced vital capacity percentage of >= 60% (n=113) and <60% (n=18). Both groups were compared in terms of laboratory and clinical characteristics, and postoperative complications. Risk factors for postoperative 28-day mortality were analyzed. Results: Pre- and intraoperative characteristics were similar in both groups, except for left ventricular end-diastolic diameter. the ventilator-free days up to 28 days was shorter (p= 0.046) and the length of intensive care unit stay was longer (p=0.011) in the low percentage of forced vital capacity group. the 28-day mortality rate was also higher (22.2% vs. 9.7%, respectively; p=0.12) in this group. the history of prior cardiac operation (odds ratio: 4.40; 95% confidence interval 1.19-16.20, p=0.026) and tricuspid valve repair at the time of device implantation (odds ratio: 5.30; 95% confidence interval 1.33-21.00, p= 0.018) were found to be independent risk factors for mortality. Multivariate analysis showed that a forced vital capacity of <60% was not associated with mortality (odds ratio: 3.96; 95% confidence interval 0.95-16.43, p=0.058). Conclusion: the length of intensive care unit stay and duration of mechanical ventilation may be longer in patients with a low percentage of forced vital capacity. Although the association between 28- day mortality and low percentage of forced vital capacity is not significant, the risk of 28-day mortality is higher in this group. Therefore, the patients should be assessed carefully before the left ventricular assist device operation.en_US
dc.description.sponsorshipAmerican Thoracic Society (ATS); ATS Methods in Epidemiologic, Clinical, and Operations Research (MECOR) Programen_US
dc.description.sponsorshipThe authors acknowledge and thank the American Thoracic Society (ATS); the ATS Methods in Epidemiologic, Clinical, and Operations Research (MECOR) Program; and particularly Damon Scales and Neill Adhikari for their supports about designing of the study.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2020.19768
dc.identifier.endpage585en_US
dc.identifier.issn1301-5680
dc.identifier.issn1301-5680en_US
dc.identifier.issue4en_US
dc.identifier.startpage576en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2020.19768
dc.identifier.urihttps://hdl.handle.net/11454/61868
dc.identifier.volume28en_US
dc.identifier.wosWOS:000582714700002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectComplicationen_US
dc.subjectheart failureen_US
dc.subjectheart-assist deviceen_US
dc.subjectmortalityen_US
dc.subjectpulmonary function testen_US
dc.titleAssociation between the low percentage of forced vital capacity and increased mortality after left ventricular assist device implantationen_US
dc.typeArticleen_US

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