Imaging of bacterial infection with 99mTc-labeled HBD-1

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dc.contributor.authorYurt Lambrecht F.
dc.contributor.authorYilmaz O.
dc.contributor.authorUnak P.
dc.contributor.authorSeyitoglu B.
dc.contributor.authorDurkan K.
dc.contributor.authorYolcular S.
dc.contributor.authorBaskin H.
dc.date.accessioned2019-10-26T23:56:43Z
dc.date.available2019-10-26T23:56:43Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate 99mTc labeled human ß-defensin-1 (HBD-1) for discrimination between bacterial infection and sterile inflammation. For this purpose, HBD-1 was radiolabeled with 99mTc and its in vivo distribution was evaluated in inflamed rats with Staphylococcus aureus (S. aureus) and sterile inflamed rats with turpentine oil. After injection into inflamed and sterile inflamed rats, 99mTc-HBD-1 was rapidly removed from the circulation via the kidneys. Binding of 99mTc-HBD-1 to inflamed muscle (T/NT = 20 at 120 min) was two times higher than binding to sterile inflamed muscle (T/NT = 10 at 120 min) of rats. It was demonstrated that 99mTc-HBD-1 can be used to detect S. aureus inflammation in rats. However, the radiolabeled antimicrobial peptide showed only poor uptake in sterile inflammation with turpentine oil in rats. As a result, 99mTc-HBD-1 can be useful for detection of bacterial inflammation. © 2008 Akadémiai Kiadó, Budapest.en_US
dc.description.sponsorshipThe authors gratefully acknowledge the financial support received from T.R Prime Ministry State Planning Organization. --en_US
dc.identifier.doi10.1007/s10967-007-7135-x
dc.identifier.endpage559en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage555en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-007-7135-x
dc.identifier.urihttps://hdl.handle.net/11454/20860
dc.identifier.volume277en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleImaging of bacterial infection with 99mTc-labeled HBD-1en_US
dc.typeArticleen_US

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