Effect of antihypertensive treatment on the prevalence of ventricular arrhythmias among patients with isolated systolic hypertension without left ventricular hypertrophy

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dc.contributor.authorGurgun, C
dc.contributor.authorNalbantgil, S
dc.contributor.authorNalbantgil, I
dc.contributor.authorZoghi, M
dc.contributor.authorYilmaz, H
dc.contributor.authorBoydak, B
dc.contributor.authorOnder, R
dc.date.accessioned2019-10-27T18:18:30Z
dc.date.available2019-10-27T18:18:30Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The high incidence of ventricular arrhythmias in patients with hypertension and left ventricular hypertrophy (LVH) is well documented. However, few studies have been conducted on the prevalence of ventricular arrhythmias in patients with isolated systolic hypertension without LVH. Objectives: The objectives of this study were to (1) determine the prevalence of ventricular arrhythmias in patients with systolic hypertension without LVH and (2) estimate the effect of a perindopril/indapamide combination, which does not have an antiarrhythmic effect, on the incidence of ventricular arrhythmias. Methods: Patients with newly diagnosed isolated systolic hypertension (systolic blood pressure [SBP] >160 mm Hg) and a control group of normotensive patients were enrolled. During the 2-week washout period, patients underwent physical examination (including blood pressure measurements), ambulatory electrocardiography monitoring, echocardiography, and laboratory urine and blood tests. Absence of LVH was confirmed by echocardiographic examination. The group of hypertensive patients received 1 tablet of 2 mg perindopril/0.625 mg indapamide per day for a total of 4 weeks. Physical examinations and ambulatory electrocardiographic monitoring were repeated after treatment. Results: A total of 60 hypertensive (mean age, 63.1 years; mean SBP, 176.8 +/- 3.1 mm Hg; mean diastolic blood pressure, 82.6 +/- 2.9 mm Hg) and 60 normotensive patients were enrolled. Ambulatory electrocardiographic monitoring indicated that 18 of the 60 hypertensive patients (30%) had ventricular arrhythmias: 17 had ventricular premature contractions (>100/24 h) and 1 had ventricular tachycardia plus ventricular premature contractions. In the control group, 7 of 60 subjects (11.7%) had ventricular premature contractions. The difference between the 2 groups in incidence of ventricular arrhythmias was significant (P < 0.01). After treatment, mean SBP decreased to 136.1 +/- 3.2 mm Hg, and ventricular premature contractions were found in 9 of 60 hypertensive patients (15%) (P < 0.02 vs pretreatment). Conclusions: The results of this study suggest that in patients with isolated systolic hypertension without LVH, (1) the prevalence of ventricular arrhythmia is higher than in normotensive patients and (2) treatment with perindopril/ indapamide decreases the incidence of ventricular arrhythmias.en_US
dc.identifier.doi10.1016/S0011-393X(02)80004-2
dc.identifier.endpage32en_US
dc.identifier.issn0011-393X
dc.identifier.issn0011-393Xen_US
dc.identifier.issue1en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.1016/S0011-393X(02)80004-2
dc.identifier.urihttps://hdl.handle.net/11454/35495
dc.identifier.volume63en_US
dc.identifier.wosWOS:000173458000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherExcerpta Medica Incen_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical and Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsystolic hypertensionen_US
dc.subjectventricular arrhythmiasen_US
dc.subjectperindopril/indapamideen_US
dc.titleEffect of antihypertensive treatment on the prevalence of ventricular arrhythmias among patients with isolated systolic hypertension without left ventricular hypertrophyen_US
dc.typeArticleen_US

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