Multimodal theranostic assemblies: double encapsulation of protoporphyrine-IX/Gd3+ in niosomes

Basit Öğe Kaydı
dc.contributor.authorBarlas, F. Baris
dc.contributor.authorDemir, Bilal
dc.contributor.authorGuler, Emine
dc.contributor.authorSenisik, A. Murat
dc.contributor.authorArican, H. Armagan
dc.contributor.authorUnake, Perihan
dc.contributor.authorTimur, Suna
dc.date.accessioned2019-10-27T22:58:46Z
dc.date.available2019-10-27T22:58:46Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractTheranostic therapy is one of the most promising methods in cancer research, which simultaneously allows the treating and real-time monitoring of cancer. In the present study, a new method was developed to achieve advanced theranostic therapy by double encapsulation of gadolinium nanoparticles (GdNP) and protoporphyrin IX (PpIX) into niosomes. Hereby, niosomes are used for encapsulation of GdNP and PpIX, which will be called 'Gd-PpIX-NI'. Niosomes are chosen as the encapsulation material owing to their high biocompatibility, physical and chemical stability, and fair price. On the other hand, GdNP and PpIX are good sensitizers for radiotherapy (RT) and, particularly, porphyrin structures are one of the most studied agents for photodynamic therapy (PDT). In this study, a multimodal treatment was performed with the combination of PDT and RT by using human alveolar type-II (ATII)-like cells (A549) and human cervical cancer cell line (HeLa). Moreover, 'Gd-PpIX-NI' serves as a dual cell imaging probe that provides both fluorescence and magnetic resonance imaging. Characterization of the sizes and zeta potential of the niosomal vesicles was carried out by dynamic light scattering and atomic force microscopy. To determine the cell viability after treatment with Gd-PpIX-NI, followed by PDT and RT application, the MTT method was used. The results showed that Gd-PpIX-NI assembling was homogeneous and consistent in terms of particle size, which is less than 100 nm. This material has potential as a good candidate for both PDT and RT, as well as diagnosis.en_US
dc.description.sponsorshipEge University Scientific Research ProjectEge University [2011/FEN/055]en_US
dc.description.sponsorshipThis work was supported by Ege University Scientific Research Project (2011/FEN/055).en_US
dc.identifier.doi10.1039/c5ra26737d
dc.identifier.endpage30225en_US
dc.identifier.issn2046-2069
dc.identifier.issn2046-2069en_US
dc.identifier.issue36en_US
dc.identifier.startpage30217en_US
dc.identifier.urihttps://doi.org/10.1039/c5ra26737d
dc.identifier.urihttps://hdl.handle.net/11454/51640
dc.identifier.volume6en_US
dc.identifier.wosWOS:000373061600042en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofRsc Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleMultimodal theranostic assemblies: double encapsulation of protoporphyrine-IX/Gd3+ in niosomesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu