Thymidine kinase enzyme selective imaging radiopharmaceutical: Tc-99m(CO)(3)-Ganciclovir

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dc.contributor.authorGedik, B.
dc.contributor.authorTeksoz, S.
dc.contributor.authorIchedef, C.
dc.contributor.authorKilcar, A. Y.
dc.contributor.authorMedine, E. I.
dc.contributor.authorUcar, E.
dc.date.accessioned2019-10-27T21:55:39Z
dc.date.available2019-10-27T21:55:39Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study is to radiolabel ganciclovir, known as having selective antiviral properties against thymidine kinase, with technetium tricarbonylcore (Tc-99m(CO)(3)(+)) and to investigate the biological behavior of this complex in vitro and in vivo. Commercially provided Ganciclovir (GCV) was radiolabeled with Tc-99m(CO)(3)(+). Initially, optimum radiolabeling conditions were determined by analyzing factors such as temperature, pH and time. Quality control of the radiolabeled compound was performed. The radiolabeling yield was found to be 97%. The Tc-99m(CO)(3)-GCV complex also displayed good in vitro stability during the 24 h period. In vitro cell uptake studies showed that the Tc-99m(CO)(3)-GCV complex is highly uptaken in A-549, PC-3, HeLa cell lines according to the control group Tc-99m(I)-tricarbonyl core. The knowledge gained from in vivo and in vitro studies of Tc-99m(CO)(3)-GCV could contribute to the development of a new HSV1-tk gene imaging agent.en_US
dc.description.sponsorshipEge University (Bornova Izmir, Turkey)Ege University [2010NBE006]en_US
dc.description.sponsorshipThis study was financially supported by the Ege University Scientific Research Project numbered 2010NBE006 (Bornova Izmir, Turkey).en_US
dc.identifier.doi10.1524/ract.2013.2003
dc.identifier.endpage128en_US
dc.identifier.issn0033-8230
dc.identifier.issue2en_US
dc.identifier.startpage123en_US
dc.identifier.urihttps://doi.org/10.1524/ract.2013.2003
dc.identifier.urihttps://hdl.handle.net/11454/48255
dc.identifier.volume101en_US
dc.identifier.wosWOS:000315178900008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofRadiochimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymidine kinaseen_US
dc.subjectGanciclovir [Tc-99m(CO)(3)](+) coreen_US
dc.subjectRadiolabelingen_US
dc.titleThymidine kinase enzyme selective imaging radiopharmaceutical: Tc-99m(CO)(3)-Gancicloviren_US
dc.typeArticleen_US

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