Autoantibodies in Patients with Fasciolosis

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dc.contributor.authorKaya, S.
dc.contributor.authorDemirci, M.
dc.contributor.authorCetin, E. Sesli
dc.contributor.authorAridogan, B. Cicioglu
dc.contributor.authorSahin, M.
dc.contributor.authorKorkmaz, M.
dc.date.accessioned2019-10-27T20:50:43Z
dc.date.available2019-10-27T20:50:43Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Antiself humoral immune responses have been detected not only in classical autoimmune diseases, but autoantibodies have also been found in sera of patients suffering from chronic parasitic diseases. We aimed to investigate the role of fasciolosis as a trigger factor of autoimmune reactivity by searching some antibodies related to hepatobiliary systems, in patients with fasciolosis. Methods: Thirty-two patients (17 males, 15 females) with fasciolosis were included in this case-control study. Anti-nuclear antibodies (ANA) Screen (antigen mixture of dsDNA, histones, nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1, ribosomal P-proteins, centromere) ELISA and single-antigen ELISAs for detection of some antibodies (dsDNA, Anti-M2. Anti-liver-kidney microsomes type 1 (LKM-1) and Myeloperoxidase (MPO) were carried out. Results: ANA-screen, M-2, LKM-1, MPO and anti-dsDNA positivity were detected with ELISA in 7,7,4,2 and 2 of 32 patients with fasciolosis, consecutively. No statistically significant difference was detected for any of the autoantibodies' frequency between patients with fasciolosis and control group. However, autoantibody positivity rate was significantly higher in patients with fasciolosis (50 %) than control group (12.5 %). Absorbance values of all autoantibodies in patients with fasciolosis were statistically significant higher than controls. Conclusion: These results lent support to the role of fasciolosis as a trigger factor of autoimmune reactivity by the breakdown of tolerance. In spite of the extensive knowledge that has accumulated, the specific relationship between fasciolosis and autoimmunity is still obscure.en_US
dc.identifier.endpage39en_US
dc.identifier.issn1735-7020
dc.identifier.issn2008-238X
dc.identifier.issn1735-7020en_US
dc.identifier.issn2008-238Xen_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://hdl.handle.net/11454/43032
dc.identifier.volume4en_US
dc.identifier.wosWOS:000270655500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIranian Scientific Society Medical Entomologyen_US
dc.relation.ispartofIranian Journal of Parasitologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFasciolosisen_US
dc.subjectAutoantibodyen_US
dc.subjectAutoimmunityen_US
dc.titleAutoantibodies in Patients with Fasciolosisen_US
dc.typeArticleen_US

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