Ultrastructural and functional effects of therapeutic dose of digoxin on rat hepatic cells

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dc.contributor.authorArcasoy M.M.
dc.date.accessioned2019-10-27T08:00:15Z
dc.date.available2019-10-27T08:00:15Z
dc.date.issued1973
dc.departmentEge Üniversitesien_US
dc.description.abstractMale Sprague Dawley rats weighing 250 to 300 g were injected with digoxin 0.03 mg/kg i.p. twice a day at 12 hr intervals for 5 days. Ultrastructural studies of the liver showed marked hypertrophy of the smooth endoplasmic reticulum (up to 3 times normal) large and dispersed nucleolus and significant glycogen accumulation. Functionally, a nonspecific response of microsomal drug metabolizing enzymes (increased activity of N demethylation of dimethylaniline and p hydroxylation of aniline) was found, but this response was of very short duration. It is suggested that the differences in toxic and therapeutic doses of digoxin account for the variability of effects of this glycoside in clinical practice.en_US
dc.identifier.endpage37en_US
dc.identifier.issn0304-4939
dc.identifier.issn0304-4939en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://hdl.handle.net/11454/24662
dc.identifier.volume2en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofAegean Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleUltrastructural and functional effects of therapeutic dose of digoxin on rat hepatic cellsen_US
dc.typeArticleen_US

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