Material Design in Implantable Biosensors toward Future Personalized Diagnostics and Treatments

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dc.authorscopusid57199103659
dc.authorscopusid57188963997
dc.authorscopusid57564391200
dc.authorscopusid6701638388
dc.contributor.authorGhorbanizamani, Faezeh
dc.contributor.authorMoulahoum, Hichem
dc.contributor.authorCelik, Emine Guler
dc.contributor.authorTimur, Suna
dc.date.accessioned2024-08-25T18:53:03Z
dc.date.available2024-08-25T18:53:03Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThe growing demand for personalized treatments and the constant observation of vital signs for extended periods could positively solve the problematic concerns associated with the necessity for patient control and hospitalization. The impressive development in biosensing devices has led to the creation of man-made implantable devices that are temporarily or permanently introduced into the human body, and thus, diminishing the pain and discomfort of the person. Despite all promising achievements in this field, there are some critical challenges to preserve reliable functionality in the complex environment of the human body over time. Biosensors in the in vivo environment are required to have specific features, including biocompatibility (minimal immune response or biofouling), biodegradability, reliability, high accuracy, and miniaturization (flexible, stretchable, lightweight, and ultra-thin). However, the performance of implantable biosensors is limited by body responses and insufficient power supplies (due to minimized batteries/electronics and data transmission without wires). In addition, the current processes and developments in the implantable biosensors field will open new routes in biomedicine and diagnostic systems that monitor occurrences happening inside the body in a certain period. This topical paper aims to give an overview of the state-of-the-art implantable biosensors and their design methods. It also discusses the latest developments in material science, including nanomaterials, hydrogel, hydrophilic, biomimetic, and other polymeric materials to overcome failures in implantable biosensors' reliability. Lastly, we discuss the main challenges faced and future research prospects toward the development of dependable implantable biosensors.en_US
dc.identifier.doi10.3390/app13074630
dc.identifier.issn2076-3417
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85152543349en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/app13074630
dc.identifier.urihttps://hdl.handle.net/11454/102957
dc.identifier.volume13en_US
dc.identifier.wosWOS:000971900700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofApplied Sciences-Baselen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectimplantable biosensorsen_US
dc.subjectdiagnosticsen_US
dc.subjecttherapyen_US
dc.subjectpolymersen_US
dc.subjectnanomaterialsen_US
dc.subjectcompositesen_US
dc.subjectCarbon Nanotubesen_US
dc.subjectTissue-Responseen_US
dc.subjectReal-Timeen_US
dc.subjectSensorsen_US
dc.subjectMembraneen_US
dc.subjectWirelessen_US
dc.subjectSystemsen_US
dc.subjectBiocompatibilityen_US
dc.subjectThicknessen_US
dc.subjectCoatingsen_US
dc.titleMaterial Design in Implantable Biosensors toward Future Personalized Diagnostics and Treatmentsen_US
dc.typeReview Articleen_US

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