The mechanism of the antipolyuric action of amiloride in lithium- treated rats

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dc.contributor.authorCan C.
dc.contributor.authorTuglular I.
dc.contributor.authorBoztok N.
dc.contributor.authorDorhout Mees E.
dc.date.accessioned2019-10-27T09:00:35Z
dc.date.available2019-10-27T09:00:35Z
dc.date.issued1998
dc.departmentEge Üniversitesien_US
dc.description.abstractPolyuria is a frequent complication in lithium-treated patients. Amiloride, a potassium sparing diuretic was shown to improve the polyuric effect of lithium in both experimental animals and men. However, the mechanism of this action is debated. In this study, we aimed to differentiate between the two possible mechanisms of this action which were previously suggested by different authors. In lithium-treated rats with severe polyuria, amiloride administration (1.2 mg/kg/day intraperitoneally, for 1 week) decreased the mean urine volume significantly from a mean of 147.5 ± 16.1 ml/day to 51.7 ± 4.75 ml/day (p < 0.05). In this dosage amiloride also decreased the urinary potassium excretion from a mean of 4.01 ± 0.36 mmol/day to 2.49 ± 0.39 mmol/day (p < 0.05) with no significant changes in urinary sodium and lithium excretions. There were no significant changes in plasma Na+, K+ and Li+ levels after amiloride consumption. Amiloride also had a protective effect when administered prior to lithium. These results suggest that the effect of amiloride is due to a direct action on distal tubular cells rather than to volume depletion as is seen after thiazide administration.en_US
dc.identifier.doi10.1002/(SICI)1099-1077(199804)13:3<211
dc.identifier.endpage215en_US
dc.identifier.issn0885-6222
dc.identifier.issn0885-6222en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage211en_US
dc.identifier.urihttps://doi.org/10.1002/(SICI)1099-1077(199804)13:3<211
dc.identifier.urihttps://hdl.handle.net/11454/28091
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofHuman Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmilorideen_US
dc.subjectDiureticen_US
dc.subjectLithiumen_US
dc.subjectPolyuriaen_US
dc.subjectRaten_US
dc.titleThe mechanism of the antipolyuric action of amiloride in lithium- treated ratsen_US
dc.typeArticleen_US

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