Tc-99m-glucoheptonate-guanine: Synthesis, biodistribution and imaging in animals

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dc.contributor.authorUnak, P.
dc.contributor.authorTeksoz, S.
dc.contributor.authorMuftuler, F. Z. Biber
dc.contributor.authorMedine, E. I.
dc.contributor.authorAcar, C.
dc.contributor.authorYurekli, Y.
dc.date.accessioned2019-10-27T19:55:42Z
dc.date.available2019-10-27T19:55:42Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of the current study was to design a nucleotide-based radiopharmaceutical which could be labeled with Tc-99m and to investigate its radiopharmaceutical efficiency and stability. GHA (glucoheptonate) was used as bifunctional chelate. GHA was labeled with Tc-99m by SnCl2 reduction method first, and then G (guanine) was conjugated with Tc-99m-GHA at 90 C. In order to determine its radiopharmaceutical stability, thin layer radio chromatography (TLRC) and electrophoresis were employed. In addition, the results were confirmed using high performance liquid radio chromatography (HPLRC). Scintigraphic imaging was performed on rats with mammary tumors, while tissue distribution was determined on Albino Wistar rats. Labeling yield was found to be over 95% and the labeled complex maintained its stability during the study period. The lipophilicity of the Tc-99m-GHG was measured and the partition coefficient (logP) of the labeled compound calculated. The results demonstrated that the uptake of Tc-99m-GHG (Tc-99m-glucoheptonate-guanine) reached its maximum at 3 hours p.i. in stomach and intestines. Main way of excretion was renal. Hepatobiliary excretion was also observed. In conclusion, Tc-99m-GHG may be useful as a nucleotide-based radiopharmaceutical for in vivo applications.en_US
dc.identifier.doi10.1007/s10967-007-6934-4
dc.identifier.endpage385en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue2en_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-007-6934-4
dc.identifier.urihttps://hdl.handle.net/11454/40722
dc.identifier.volume275en_US
dc.identifier.wosWOS:000252891400020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleTc-99m-glucoheptonate-guanine: Synthesis, biodistribution and imaging in animalsen_US
dc.typeArticleen_US

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