COVID-19 Disease and Hereditary Angioedema
| dc.contributor.author | Asik, Aycan | |
| dc.contributor.author | Mete Gokmen, Nihal | |
| dc.date.accessioned | 2021-05-03T20:38:39Z | |
| dc.date.available | 2021-05-03T20:38:39Z | |
| dc.date.issued | 2020 | |
| dc.department | Ege Üniversitesi | en_US |
| dc.description.abstract | Since December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) infection causing COVID-19 disease has influenced the whole world. Angiotensin converting enzyme 2 (ACE2) receptors on type 2 pneumocytes in humans were determined as the entry for SARS-CoV-2. Receptor binding and subsequently endocytosis of ACE2 diminish the cell membrane expression and also the function of ACE2. ACE2 is an enzyme involved in bradykinin metabolism. Lys-des-Arg9-BK occured with enzymatic cleaving of Lys-BK derived from low molecular weight kininogen is inactivated by ACE2 in tissues and it is a vasodilator agent having its own receptor named bradykinin B1. Non-metabolized Lys-des-Arg9-BK can be the reason for tissue vasodilation and increased vascular permeability in the patients with COVID-19. Increased bradykinin levels in patients with hereditary angioedema with C1-INH deficiency (C1-INH-HAE) do not cause increased SARS-CoV-2 infection or more severe disease. Although SARS-CoV-2 infection does not result in increased bradykinin levels, it can increase Lys-des-Arg9-BK levels. | en_US |
| dc.identifier.doi | 10.21911/aai.562 | |
| dc.identifier.endpage | 22 | en_US |
| dc.identifier.issn | 1308-9234 | |
| dc.identifier.startpage | 19 | en_US |
| dc.identifier.uri | https://doi.org/10.21911/aai.562 | |
| dc.identifier.uri | https://hdl.handle.net/11454/70509 | |
| dc.identifier.volume | 18 | en_US |
| dc.identifier.wos | WOS:000592369300006 | en_US |
| dc.identifier.wosquality | N/A | en_US |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Bilimsel Tip Yayinevi | en_US |
| dc.relation.ispartof | Astim Allerji Immunoloji | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | COVID-19 | en_US |
| dc.subject | SARS-CoV-2 | en_US |
| dc.subject | hereditary angioedema | en_US |
| dc.subject | ACE2 receptors | en_US |
| dc.subject | bradykinin | en_US |
| dc.subject | Lys-des-Arg9-BK | en_US |
| dc.title | COVID-19 Disease and Hereditary Angioedema | en_US |
| dc.type | Review Article | en_US |
