HYPERICUM PERFORATUM L.: AN OVERVIEW OF THE ANTICANCER POTENCIES OF THE SPECIMENS COLLECTED FROM DIFFERENT ECOLOGICAL ENVIRONMENTS

Basit Öğe Kaydı
dc.contributor.authorGonenc, Tuba Mert
dc.contributor.authorOzturk, Munir
dc.contributor.authorTurkseven, Suleyman Gurdal
dc.contributor.authorKirmizibayrak, Petek Ballar
dc.contributor.authorGunal, Selin
dc.contributor.authorYilmaz, Sinem
dc.date.accessioned2020-12-01T12:01:11Z
dc.date.available2020-12-01T12:01:11Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractHypericum genus holds an important place in the flora of Turkey with 46 endemic species out of its naturally growing 96 species. H. perforatum is the most popular and common species. This species has been traditionally used in pain control, wound healing and especially as antidepressant. Its anticancer effects have been lately attracting much attention. To investigate and compare the antiproliferative effects of extracts of the samples collected from eleven different "States" of Turkey. the antiproliferative effect of extracts was determined by WST-1 method on HeLa, U2OS, HCC-1937 cancer cells and MRC-5 noncancer fibroblast cells. Furthermore, cell death mechanism of the extracts was analyzed by investigating the cleavage level of caspase-7 and PARP-1, which are hallmarks of apoptosis and also the levels of LC3-II and p62 protein levels as markers of autophagy. Only HP10 (collected from Cankm-Ilgaz) was found to induce apoptosis both using immunoblotting and flow cytometry analysis, while almost all of the extracts cause the induction of autophagy in HeLa cells at their IC50 values. HP10 coded sample was collected from the transition zone between the Black Sea and Central Anatolian Regions, the collection area with highest altitude. According to our results different climatic features effect plant contents as well as their therapeutic effects. Moreover, the amount of compounds that have anticancer activity in the plant undergo a change with altitude.en_US
dc.identifier.doi10.30848/PJB2020-3(24)
dc.identifier.endpage1010en_US
dc.identifier.issn0556-3321
dc.identifier.issn2070-3368
dc.identifier.issn0556-3321en_US
dc.identifier.issn2070-3368en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85083018330en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1003en_US
dc.identifier.urihttps://doi.org/10.30848/PJB2020-3(24)
dc.identifier.urihttps://hdl.handle.net/11454/62334
dc.identifier.volume52en_US
dc.identifier.wosWOS:000522404600031en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPakistan Botanical Socen_US
dc.relation.ispartofPakistan Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiproliferative effectsen_US
dc.subjectApoptosisen_US
dc.subjectAutophagyen_US
dc.subjectCanceren_US
dc.subjectCytotoxicityen_US
dc.subjectHypericum perforatumen_US
dc.titleHYPERICUM PERFORATUM L.: AN OVERVIEW OF THE ANTICANCER POTENCIES OF THE SPECIMENS COLLECTED FROM DIFFERENT ECOLOGICAL ENVIRONMENTSen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu