The role of familial mediterranean fever gene mutation in treatment of infantile colitis with resistant perianal fistula

Basit Öğe Kaydı
dc.contributor.authorBaran M.
dc.contributor.authorÇağan Appak Y.
dc.contributor.authorGaripcin P.
dc.contributor.authorDemirçelik Y.
dc.contributor.authorPala E.E.
dc.contributor.authorÖzyilmaz B.
dc.contributor.authorKarakoyun M.
dc.contributor.authorErgün O.
dc.date.accessioned2019-10-27T08:01:37Z
dc.date.available2019-10-27T08:01:37Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractSymptoms of infantile inflammatory bowel disease (I-IBD) can be life-threatening and associated with poor prognosis. The presence of Mediterranean fever (MEFV) gene mutations play an important role in treatment of I-IBD. In this article, we describe a case of I-IBD with a resistant fistula, in which remission occurred following colchicine therapy. The patient was a six-month-girl with complaints of bloody diarrhea and a perianal abscess of three months duration. Laboratory tests revealed elevated inflammatory parameters, hypoalbuminemia, and anemia. Results of repeated viral, bacterial and parasitic analyses were negative. Endoscopic and histopathological examinations confirmed a diagnosis of I-IBD. Although diarrhea episodes decreased following intensive conventional treatment with immunosuppressive therapy and anti-tumor necrosis factor, the perianal abscess and fistula did not resolve. Molecular genetic analysis to identify causes of infantile disease revealed the MEFV gene mutation. Thus, colchicine was added to the treatment regimen. Following treatment with colchicine, defecation returned to normal, and the fistula resolved. The MEFV gene mutation should be investigated in children with infantile colitis and resistant fistulas, particularly in Mediterranean countries. In patients with infantile colitis who have the MEFV gene mutation, colchicine treatment may be an alternative to intensive immunosuppressive therapy. © 2018, Turkish League Against Rheumatism (TLAR). All rights reserved.en_US
dc.identifier.doi10.5606/ArchRheumatol.2018.6741
dc.identifier.endpage477en_US
dc.identifier.issn2148-5046
dc.identifier.issn2148-5046en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage473en_US
dc.identifier.urihttps://doi.org/10.5606/ArchRheumatol.2018.6741
dc.identifier.urihttps://hdl.handle.net/11454/25032
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish League Against Rheumatism (TLAR)en_US
dc.relation.ispartofArchives of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColchicineen_US
dc.subjectInfantile colitisen_US
dc.subjectPerianal fistulaen_US
dc.titleThe role of familial mediterranean fever gene mutation in treatment of infantile colitis with resistant perianal fistulaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu