Anti-proliferative and Apoptotic Effects of Coordination Compounds of Zinc(II), Palladium(II), and Platinum(II) with Tridentate 4-(6-hydroxyphenyl)-2,6-di(thiazol-2-yl)pyridine
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The mononuclear coordination compounds, [Zn(L)Cl-2] (1), [Pd(L)Cl]Cl (2), and [Pt(L)Cl]Cl (3) (L) is a tridentate-coordinated of 4-(6-hydroxyphenyl)-2,6-di(thiazol-2-yl)pyridine) were synthesized and characterized by different spectroscopic methods (FTIR, MALDI-TOF-MS, H-1 NMR, C-13 NMR, and UV/Vis). By using density functional theory (DFT) and time-dependent DFT (TD-DFT) methods, the geometrical parameters, UV/Vis absorption spectra, and infrared vibrational frequencies for the investigated compounds were explored. Anticancer activities of these compounds were determined by SRB viability assay in human lung (A549 and H1299), prostate (LNCAP), colorectal (HT-29), breast cancer (MDA-MB-231) and healthy bronchial (BEAS-2B), breast (MCF-10A), colon (CCD-18Co), and prostate (WPMY-1) epithelial cells. Caspase 3/7 activity, cleaved cytokeratin-18, and PARP levels were measured to determine apoptosis in the metal compounds found to be effective. Among the compounds, 1 showed a selective inhibiting effect and induced apoptosis on the cancer cells, thus further analyses are needed to evaluate its antitumor/anticancer activity.
Açıklama
Anahtar Kelimeler
Apoptosis, Cancer cells, Cytotoxicity, Terpyridine analog compounds, Copper(Ii) Complexes, Metal-Complexes, Anticancer Activity, Crystal-Structure, Cancer, Dna, Derivatives, Protein
Kaynak
Chemistryselect
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
8
Sayı
13
