Preliminary tests of the radiopharmaceutical potential of N-(2,6-diisopropylphenyl)-N'-(4-pyridyl)-perylene-3,4,9,10-tetracarboxylic diimide radiolabeled with I-131

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dc.contributor.authorAvcibasi, U.
dc.contributor.authorDincalp, H.
dc.contributor.authorUenak, T.
dc.contributor.authorYildirim, Y.
dc.contributor.authorAvcibasi, N.
dc.contributor.authorDuman, Y.
dc.contributor.authorIcli, S.
dc.date.accessioned2019-10-27T19:32:47Z
dc.date.available2019-10-27T19:32:47Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractPerylene diimide derivatives are one of the G-quadruplex DNA interactive agents which are thought to be useful in application of cancer treatment Starting from this consideration, N-(2,6-diisopropylphenyl)-N'-(4-pyridyl)-perylene-3,4,9,10-tetracarboxylic diimide (PYPER) was synthesized, radioiodinated with I-131, and its radiopharmaceutical potentials were tested on a male Albino rabbit and male Albino Wistar rats. This compound was successfully radioiodinated with I-131 with a radioiodination yield of about 100%. Scintigraphic imaging with the radiiodinated compound (I-131-PYPER) was performed on a rabbit. Static images were obtained from posterior projection using a Diacan gamma camera at several time intervals. The scintigrams clearly showed that the radioiodinated compound was not quickly cleared from the metabolism, accumulating in the stomach over about 30 minutes. The clearance time of this compound was considerably longer than 5 hours. The results obtained in this study agreed with that of the biodistribution studies and indicated that I-131-PYPER might be used as a scintigraphic agent for examining stomach diseases.en_US
dc.identifier.doi10.1007/s10967-007-0929-z
dc.identifier.endpage675en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.startpage669en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-007-0929-z
dc.identifier.urihttps://hdl.handle.net/11454/39356
dc.identifier.volume273en_US
dc.identifier.wosWOS:000248612300029en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePreliminary tests of the radiopharmaceutical potential of N-(2,6-diisopropylphenyl)-N'-(4-pyridyl)-perylene-3,4,9,10-tetracarboxylic diimide radiolabeled with I-131en_US
dc.typeArticleen_US

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