Cycloartane-type glycosides from Astragalus brachycalyx FISCHER and their effects on cytokine release and hemolysis

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dc.contributor.authorAslanipour, Behnaz
dc.contributor.authorGulcemal, Derya
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorYusufoglu, Hasan
dc.contributor.authorBedir, Erdal
dc.date.accessioned2019-10-27T11:05:42Z
dc.date.available2019-10-27T11:05:42Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractTwo new tridesmosidic cycloartane-type triterpene glycosides (1 and 2) were isolated from the methanolic extract of the roots of Astragalus brachycalyx FISCHER (A. brachycalyx) along with ten (3-12) known cycloartanetype triterpene glycosides. Structures of the new compounds were established as 3-O-beta-D-xylopyranosyl-6-O-beta-Dglucopyranosyl- 16-O-beta-D-glucopyranosyl-3 beta, 6a, 16 beta, 24(S)-25-pentahydroxycycloartane (1), 3-O-[a-L-arabinopyranosyl-(1. 2)-beta-D-xylopyranosyl]-6-O-beta-D-glucopyranosyl-16-O-beta-D-glucopyranosyl-3 beta, 6 alpha, 16 beta, 24(S)-25-pentahydroxycycloartane (2), by using 1D and 2D-NMR techniques and mass spectrometry. In vitro immunomodulatory effects and hemolytic activities of the new saponins (1 and 2) and acetylated form of 1 (1a) were studied together with the BuOH and MeOH extracts of Astragalus brachycalyx. The results have proven that tridesmosidic Astragalus cycloartanes are noteworthy immunomodulatory compounds via induction of cytokine production, namely IL-2 and IFN-gamma. The test compounds also resulted slight hemolysis at very high doses substantiating a safer profile compared to the positive control QS-21.en_US
dc.description.sponsorshipEge University Research FoundationEge University [15-FBE-001]en_US
dc.description.sponsorshipThe authors gratefully acknowledge to the financial support of Ege University Research Foundation (15-FBE-001) for the finical support and thank Prof. Dr. Ali Asghar Maassoumi for the identification of the plant material, and special thanks to NMR operators of both Ege University and Prince Sattam bin Abdulaziz University namely Salih Gunnaz and Anzarul Haque, respectively.en_US
dc.identifier.doi10.1016/j.phytol.2017.05.028
dc.identifier.endpage73en_US
dc.identifier.issn1874-3900
dc.identifier.issn1876-7486
dc.identifier.issn1874-3900en_US
dc.identifier.issn1876-7486en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage66en_US
dc.identifier.urihttps://doi.org/10.1016/j.phytol.2017.05.028
dc.identifier.urihttps://hdl.handle.net/11454/31718
dc.identifier.volume21en_US
dc.identifier.wosWOS:000414229300014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofPhytochemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAstragalus brachycalyxen_US
dc.subjectFabaceaeen_US
dc.subjectSaponinsen_US
dc.subjectCycloartaneen_US
dc.subjectCytokine stimulationen_US
dc.subjectHemolytic activityen_US
dc.titleCycloartane-type glycosides from Astragalus brachycalyx FISCHER and their effects on cytokine release and hemolysisen_US
dc.typeArticleen_US

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