Hemophagocytic lymphohistiocytosis in adults: Low incidence of primary neoplasm as a trigger in a case series from Turkey

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dc.contributor.authorArslan F.
dc.contributor.authorAlp S.
dc.contributor.authorBüyükasık Y.
dc.contributor.authorOzkan M.C.
dc.contributor.authorŞahin F.
dc.contributor.authorBasaran S.
dc.contributor.authorCagatay A.A.
dc.contributor.authorEraksoy Ö.H.
dc.contributor.authorAksu K.
dc.contributor.authorErtunç B.
dc.contributor.authorKorten V.
dc.contributor.authorCeylan B.
dc.contributor.authorMert A.
dc.date.accessioned2019-10-26T21:15:56Z
dc.date.available2019-10-26T21:15:56Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractHemophagocytic Lymphohistiocytosis (HLH) is an indicator of an exaggerated immune response and eventually adverse outcomes. This study aimed to investigate the clinical and laboratory features and outcomes of patients with HLH. The medical records of 26 HLH adult patients (? 16 years of age) were retrospectively analyzed. Gender, age, the duration of fever, time to diagnosis, etiology and laboratory data were extracted from the records. The mean age was 38 ± 18 years, and 15 (58%) patients were female. A total of nine cases had infectious diseases; four cases had rheumatologic diseases, three cases had hematological malignancies while nine cases could not have a definitive diagnosis. The median time to detection of HLH was 20 days (IQR: 8-30 d). Of the 25 patients, 11 (44%) died. The erythrocyte sedimentation rates of the surviving and non-surviving patients were 39 ± 22 mm/h and 15 ± 13 mm/h, respectively. When a long-lasting fever is complicated by bicytopenia or pancytopenia (especially), clinicians should promptly consider the possibility of HLH syndrome to improve patients' prognosis. © 2018 Slovensko Kemijsko Drustvo. All Rights Reserved.en_US
dc.identifier.doi10.4084/mjhid.2018.047
dc.identifier.issn2035-3006
dc.identifier.issn2035-3006en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.4084/mjhid.2018.047
dc.identifier.urihttps://hdl.handle.net/11454/16122
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversita Cattolica del Sacro Cuoreen_US
dc.relation.ispartofMediterranean Journal of Hematology and Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytopeniaen_US
dc.subjectFerritinen_US
dc.subjectFever of unknown originen_US
dc.subjectHemophagocytic lymphohistiocytosisen_US
dc.titleHemophagocytic lymphohistiocytosis in adults: Low incidence of primary neoplasm as a trigger in a case series from Turkeyen_US
dc.typeArticleen_US

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