Interferon alpha-2B therapy in children with chronic idiopathic thrombocytopenic purpura

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dc.contributor.authorKavakli K.
dc.contributor.authorNisli G.
dc.contributor.authorCetingul N.
dc.contributor.authorVergin C.
dc.contributor.authorOztop S.
dc.date.accessioned2019-10-27T00:33:14Z
dc.date.available2019-10-27T00:33:14Z
dc.date.issued1995
dc.departmentEge Üniversitesien_US
dc.description.abstractChronic idiopathic thrombocytopenic purpura (ITP), a well-defined autoimmune hematologic disorder, occurs more commonly in adults than in children. Chronic ITP can pose overwhelming clinical problems if conventional therapy such as steroids, splenectomy and intravenous immunglobulin therapy have failed. In our study in five children with chronic refractory ITP, a short course of recombinant alpha IFN-2b (r IFN) was given subcutaneously, at a dose of 5 M.U/m2, three times a week, for 12 doses. Four of them were female, and their age range was 6-13 years. In three cases a significant increase in platelet count was observed, which continued during therapy; but all these three cases returned to baseline levels after discontinuation of therapy. After a one-month interval the second course of r IFN was administered and the same results were obtained. IFN was well tolerated in all cases. r IFN can be recommended as a transient therapy for unresponsive severe chronic ITP. However r IFN has not replaced other conventional therapy modalities in long term treatment.en_US
dc.identifier.endpage212en_US
dc.identifier.issn1300-0144
dc.identifier.issn1300-0144en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://hdl.handle.net/11454/24006
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalpha-Interferon-2ben_US
dc.subjectchronic ITPen_US
dc.subjectthrombocytopeniaen_US
dc.titleInterferon alpha-2B therapy in children with chronic idiopathic thrombocytopenic purpuraen_US
dc.typeArticleen_US

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