In vivo biodistribution of I-131 labeled bleomycin (BLM) and isomers (A2 and B2) on experimental animal models

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dc.contributor.authorAvcibasi, U.
dc.contributor.authorDemiroglu, H.
dc.contributor.authorUnak, P.
dc.contributor.authorMuftuler, F. Z. B.
dc.contributor.authorIchedef, C. A.
dc.contributor.authorGumuser, F. G.
dc.date.accessioned2019-10-27T21:16:06Z
dc.date.available2019-10-27T21:16:06Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractBleomycins (BLMs; BLM, A2, and B2) were labeled with I-131 and radiopharmaceutical potentials were investigated using animal models in this study. Quality control procedures were carried out using thin layer radiochromatography (TLRC), high performance liquid chromatography (HPLC), and liquid chromatography (LC/MS/MS). Labeling yields of radiolabeled BLMs were found to be 90, 68, and 71%, respectively. HPLC chromatograms were taken for BLM and cold iodinated BLM (I-127-BLM). Five peaks were detected for BLM and three peaks for I-127-BLM in the HPLC studies. Two peaks belong to isomers of BLM. The isomers of BLM were purified with using HPLC. Biological activity of BLM was determined on male Albino Wistar rats by biodistribution and scintigraphic studies were performed for BLMs by using New Zelland rabbits. The biodistribution results of I-131-BLM showed high uptake in the stomach, the bladder, the prostate, the testicle, and the spinal cord in rats. Scintigraphic results on rabbits agrees with that of biodistributional studies on rats. The scintigraphy of radiolabeled isomers (I-131-A2 and I-131-B2) are similiarly found with that of I-131-BLM.en_US
dc.description.sponsorshipCelal Bayar University Research FundCelal Bayar University [2007 FEF 007]en_US
dc.description.sponsorshipThe authors thank for the financial supports from Celal Bayar University Research Fund (Contract no. 2007 FEF 007). The authors thank Dr. Ilker Medine, Research Assistant Feray Kocan, MSc student Gokcen Topal and PhD student Yasemin Parlak for their technical assistance during the animal experiments and scintigraphic studies.en_US
dc.identifier.doi10.1007/s10967-010-0565-x
dc.identifier.endpage214en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue2en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-010-0565-x
dc.identifier.urihttps://hdl.handle.net/11454/43624
dc.identifier.volume285en_US
dc.identifier.wosWOS:000279685700006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBleomycinen_US
dc.subjectA2en_US
dc.subjectB2en_US
dc.subjectBiodistributionen_US
dc.subjectI-131en_US
dc.subjectRadioiodinationen_US
dc.subjectScintigraphyen_US
dc.titleIn vivo biodistribution of I-131 labeled bleomycin (BLM) and isomers (A2 and B2) on experimental animal modelsen_US
dc.typeArticleen_US

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