A promising radiolabeled drug delivery system for methotrexate: synthesis and in vitro evaluation of Tc-99m labeled drug loaded uniform mesoporous silica nanoparticles

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dc.authoridIchedef, Cigdem/0000-0002-1586-9521
dc.authorscopusid35956001200
dc.authorscopusid57218369603
dc.authorscopusid57290189600
dc.authorscopusid6507350118
dc.authorscopusid10739428000
dc.authorwosidMedine, Emin İlker/GLS-0483-2022
dc.contributor.authorIchedef, Cigdem
dc.contributor.authorAydin, Burcu
dc.contributor.authorHamurisci, Selin Irdel
dc.contributor.authorTeksoz, Serap
dc.contributor.authorMedine, Emin Ilker
dc.date.accessioned2023-01-12T19:50:42Z
dc.date.available2023-01-12T19:50:42Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractIn present study, we describe a promising radiolabeled drug delivery system for Methotrexate (MTX), an anticancer drug used in the treatment of breast cancer. Uniform and re-dispersible MSN were synthesized with a particle size of as 42.55 +/- 1.45 nm. Then, MTX was loaded into the surface modified MSN with DTPA over 95% loading capacity. Subsequently, MTX loaded MSN carrier system was radiolabeled with Tc-99 m (Tc-99m-MTX-MSN) with 92.20 +/- 0.8% radiolabeling yield. Furthermore, in vitro evaluation on estrogen positive (ER +) MCF7 and estrogen negative (ER-) A549 cells lines were performed for determining apoptotic and cytotoxic effects of MTX-MSN, and incorporation behavior of Tc-99m-MTX-MSN. Drug loaded MSN particles were exhibit higher uptake in MCF7 cells than A549 cells.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination Unit [2017NBE006]en_US
dc.description.sponsorshipThe authors gratefully acknowledge the support by Ege University Scientific Research Projects Coordination Unit (Funding Number: 2017NBE006).en_US
dc.identifier.doi10.1007/s10967-021-08028-9
dc.identifier.endpage1125en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85116809936en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1113en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-021-08028-9
dc.identifier.urihttps://hdl.handle.net/11454/76154
dc.identifier.volume330en_US
dc.identifier.wosWOS:000705823600003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Radioanalytical And Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug delivery systemen_US
dc.subjectIn vitroen_US
dc.subjectMesoporous silica nanoparticlesen_US
dc.subjectMethotrexateen_US
dc.subjectRadiolabelingen_US
dc.subjectColloidal Suspensionsen_US
dc.subjectBiodistributionen_US
dc.subjectSizeen_US
dc.titleA promising radiolabeled drug delivery system for methotrexate: synthesis and in vitro evaluation of Tc-99m labeled drug loaded uniform mesoporous silica nanoparticlesen_US
dc.typeArticleen_US

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