The role of thrombocyte activation on early brain injury in experimental subarachnoid hemorrhage model [Deneysel sak modelinde trombosit aktivasyonunun erken beyin hasari{dotless} gelişimindeki rolü]

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dc.contributor.authorKocaman U.
dc.contributor.authorDemirçivi Özer F.
dc.contributor.authorOran I.
dc.contributor.authorMete M.
dc.contributor.authorBurak-Atci I.
dc.contributor.authorTurhan T.
dc.contributor.authorDemirtaş E.
dc.date.accessioned2019-10-26T21:42:37Z
dc.date.available2019-10-26T21:42:37Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Thrombocyte activation is one of the mechanisms blamed for emerging of early brain injury(EBI) soon after subarachnoid hemorrhage(SAH). It is wondered by researching to what extend neuron injury is prevented by making thrombocyte inhibition in SAH model. It shows that the role of trombocyte activation on EBI. Material and Method: 21 rabbits weighting 3-5 kg are divided in 3 groups 7 each. After ether anesthesia, 0.2 cc arterial blood taking from group 1 and 2 was injected into cysterna magna and created SAH. After SAH, at regular intervals antithrombocyte drug (tirofiban) was given to group 2 intraperitoneally; no treatment was carried on group 1. 0.2 cc SF was injected into cysterna magna in group 3. Decapitation was done in 72nd hour and then ischemic brain map was done at hippocampus level. The amount of ischemic neuron was scored and statistically analyzed. Results: SAH was detected in all rabbits of group 1 and 2. There are meaningful difference between the group 1 and group 3 of scoring ischemic neuron of hippocampus's CA-3 and CA-4 areas. Whereas in group 2, which is a ischemic neuron treatment group, there is a decline in each area, this decline has reached to a statistical means only in CA-4 area. Conclusion: There can be neuronal loss due to EBI even in the area which is free from blood in experimental SAH. Decreasing the injury of neuron with an antithrombocyte medicine shows that thrombocyte activation plays a great role in pathogenesis of EBI.en_US
dc.identifier.endpage721en_US
dc.identifier.issn1300-1817
dc.identifier.issn1300-1817en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage714en_US
dc.identifier.urihttps://hdl.handle.net/11454/18357
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Neurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEarly brain injuryen_US
dc.subjectSubarachnoid hemorrhageen_US
dc.subjectThrombocyteen_US
dc.titleThe role of thrombocyte activation on early brain injury in experimental subarachnoid hemorrhage model [Deneysel sak modelinde trombosit aktivasyonunun erken beyin hasari{dotless} gelişimindeki rolü]en_US
dc.typeArticleen_US

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