Graphene quantum dots-polyfluorene hybrid nanobiosensor for mitomycin C-DNA interaction sensing

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dc.authorscopusid16021622500
dc.authorscopusid57330659200
dc.authorscopusid23012483300
dc.authorscopusid13405405500
dc.authorscopusid35575192000
dc.authorscopusid6507207018
dc.authorscopusid55964006300
dc.contributor.authorEmre, D.
dc.contributor.authorDenizhan, N.
dc.contributor.authorOzkan-Ariksoysal, D.
dc.contributor.authorBilici, A.
dc.contributor.authorSonkaya, Ö.
dc.contributor.authorAlgi, F.
dc.contributor.authorYilmaz, S.
dc.date.accessioned2024-08-25T18:36:47Z
dc.date.available2024-08-25T18:36:47Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractA novel graphene quantum dots (GQD) / polyfluorene (PF) nanocomposite was deposited on the disposable pencil tip graphite electrode (PGE) and proven to be an efficient nanosensor for analysis of the electrochemical interaction between the antitumor compound mitomycin C (MC) with double stranded DNA (ds-DNA). This modified electrode (GQD@PF-PGE) was prepared in four steps: hydrothermal, chemical oxidation, ultrasonication and electro-oxidation processes. GQD, PF, GQD@PF and GQD@PF-PGE have been characterized by different analytical techniques such as SEM, TEM, XRD, FTIR, UV–Vis, EIS. Compared to bare PGE, GQD@PF modified PGE performed approximately 56 times more sensitive analysis when evaluating the guanine oxidation signals measured by DPV. CV and EIS measurements also showed that GQD@PF-PGE possesses a fast electron transfer as compared to bare electrode and exhibit a remarkable electrocatalytic activity towards both guanine and MC electrooxidation. Comprehensive optimization studies have also been carried out for the developed new nanobiosensor. © 2023en_US
dc.description.sponsorshipFHD-2021-3698en_US
dc.description.sponsorshipThe authors thank Canakkale Onsekiz Mart University Scientific Research Commission ( FHD-2021-3698 ) for the financial support. Authors thank Dr. Alper Fitoz and Prof. Zehra Yazan for impedance measurements, and Onko Kocsel Pharmaceuticals for supplying MC.en_US
dc.identifier.doi10.1016/j.mseb.2023.116944
dc.identifier.issn0921-5107
dc.identifier.scopus2-s2.0-85174031796en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.mseb.2023.116944
dc.identifier.urihttps://hdl.handle.net/11454/100747
dc.identifier.volume299en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofMaterials Science and Engineering: Ben_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectElectrochemical DNA biosensoren_US
dc.subjectElectropolymerizationen_US
dc.subjectGraphene quantum dotsen_US
dc.subjectMitomycin Cen_US
dc.subjectPencil graphite electrodeen_US
dc.subjectPolyfluoreneen_US
dc.subjectDNAen_US
dc.subjectElectrochemical electrodesen_US
dc.subjectElectrooxidationen_US
dc.subjectGrapheneen_US
dc.subjectGraphite electrodesen_US
dc.subjectNanocrystalsen_US
dc.subjectPositive ionsen_US
dc.subjectSemiconductor quantum dotsen_US
dc.subjectAntitumor compoundsen_US
dc.subjectDisposablesen_US
dc.subjectDNA interactionen_US
dc.subjectElectrochemical DNA biosensorsen_US
dc.subjectElectrochemical interactionsen_US
dc.subjectElectropolymerisationen_US
dc.subjectMitomycin Cen_US
dc.subjectNanobiosensoren_US
dc.subjectPencil graphite electrodeen_US
dc.subjectPolyfluorenesen_US
dc.subjectElectropolymerizationen_US
dc.titleGraphene quantum dots-polyfluorene hybrid nanobiosensor for mitomycin C-DNA interaction sensingen_US
dc.typeArticleen_US

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