The effects of hydergine on the synaptic plasticity of aged rats

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dc.contributor.authorHariri N.
dc.contributor.authorFalakali B.
dc.contributor.authorAlgan O.
dc.date.accessioned2019-10-27T00:33:43Z
dc.date.available2019-10-27T00:33:43Z
dc.date.issued1994
dc.departmentEge Üniversitesien_US
dc.description.abstractContradictory results have been reported in different brain regions with regard to age-related morphological ranges. In the present study, the number of synapses (Nv), the mean synaptic length (S), and the total synaptic length of synapses/micrograph (Sv) were measured using quantitative morphometric techniques in E-PTA stained sections of the olfactory bulb from adult (12 months), old (30 months), and Hydregine-treated old (30 months) rats. In old animals, Nv and Sv were reduced; however, S was significantly increased when compared with adults. Hydergine (Codergocrine mesylate) treatment of old animals (3 mg/kg/b.w./day for 4 weeks) influenced these parameters differently: in old Hydergine-treated animals, Sv and Nv were higher and S was significantly smaller, when compared with the untreated old group. All the parameters studied were not statistically different when Hydergine-treated old rats were compared with adult animals. The present findings have been interpreted as a modulating effect of Hydergine on the morphological plasticity of the olfactory bulb synapses.en_US
dc.identifier.endpage85en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://hdl.handle.net/11454/24115
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectagingen_US
dc.subjectE-PTA stainingen_US
dc.subjecthydergine (Codergocrine mesylate)en_US
dc.subjectolfactory bulben_US
dc.subjectsynaptic plasticityen_US
dc.titleThe effects of hydergine on the synaptic plasticity of aged ratsen_US
dc.typeArticleen_US

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