Encapsulation of resveratrol in rhamnolipid-zein nanoparticles using a pH-driven method: kinetic modeling on controlled release from nanoparticles

Basit Öğe Kaydı
dc.authorscopusid58181415700
dc.authorscopusid7003325188
dc.contributor.authorKorkut, Oya Cicek
dc.contributor.authorOzdemir, Gunseli
dc.date.accessioned2024-08-25T18:32:43Z
dc.date.available2024-08-25T18:32:43Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, the encapsulation of resveratrol (Res) in zein-rhamnolipid (RL) composite nanoparticles (NPs) by a pH-driven method and its relationship with the controlled release behavior of the NPs were investigated. The properties of the produced NPs were elucidated with different zein-RL mass ratios and encapsulation of different amounts of Res. The NPs had relatively high encapsulation efficiency, loading capacity, stability, and cumulative release percentages. The SEM analysis showed the spherical NPs obtained with and without Res incorporation and the FTIR study indicated the interactions of Res with zein-RL components. The NPs had relatively good stability over a wide range of pH (4-9), salt concentration (0-200 mM) (pH = 7), and Res amount (0-160 mg) (pH = 7.4). Ultrasonic and shaking water baths were used for release studies of Res from NPs with an optimum zein-RL mass ratio of 1.0:0.6 (w/w). In vitro release studies of Res under acidic (pH = 1.2) and neutral (pH = 7.4) conditions demonstrated initial rapid release followed by slow release. The highest cumulative release percentage was obtained at pH 1.2 and 7.4 with 120 mg Res encapsulated zein-RL NPs. The release of Res from the capsules was a pH-dependent process and the cumulative release profiles were considered to be slightly higher in acidic environments. Among the controlled release kinetic models, the Weibull model gave the best fit for optimum Res-loaded NPs. Release studies indicated that zein-RL NPs have the potential to be used as delivery systems for health-promoting bioactive molecules in functional foods, nutraceutical/dietary supplements, and pharmaceutical formulations.en_US
dc.description.sponsorshipScientific Research Projects of Ege University (BAP) [FYL-2020-21282]en_US
dc.description.sponsorshipFunding sources are as stated in the acknowledgments.en_US
dc.identifier.doi10.1080/01932691.2023.2197044
dc.identifier.issn0193-2691
dc.identifier.issn1532-2351
dc.identifier.scopus2-s2.0-85152403540en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1080/01932691.2023.2197044
dc.identifier.urihttps://hdl.handle.net/11454/100308
dc.identifier.wosWOS:000963413000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Dispersion Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectNanoencapsulationen_US
dc.subjectresveratrolen_US
dc.subjectzeinen_US
dc.subjectrhamnolipiden_US
dc.subjectpH-driven methoden_US
dc.subjectcontrolled releaseen_US
dc.subjectAntisolvent Precipitationen_US
dc.subjectBiopolymer Nanoparticlesen_US
dc.subjectDrug-Releaseen_US
dc.subjectBioavailabilityen_US
dc.subjectCurcuminen_US
dc.subjectAntioxidanten_US
dc.subjectFabricationen_US
dc.subjectStabilityen_US
dc.subjectDeliveryen_US
dc.subjectAciden_US
dc.titleEncapsulation of resveratrol in rhamnolipid-zein nanoparticles using a pH-driven method: kinetic modeling on controlled release from nanoparticlesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu