Thymidine kinase enzyme selective imaging radiopharmaceutical: 99mTc(CO)3-Ganciclovir

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dc.contributor.authorGedik B.
dc.contributor.authorTeksöz S.
dc.contributor.authorIçhedef Ç.
dc.contributor.authorKilçar A.Y.
dc.contributor.authorMedine E.I.
dc.contributor.authorUçar E.
dc.date.accessioned2019-10-27T08:23:59Z
dc.date.available2019-10-27T08:23:59Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study is to radiolabel ganciclovir, known as having selective antiviral properties against thymidine kinase, with technetium tricarbonylcore (99mTc(CO)3 + and to investigate the biological behavior of this complex in vitro and in vivo. Commercially provided Ganciclovir (GCV) was radiolabeled with 99mTc(CO)3-. Initially, optimum radiolabeling conditions were determined by analyzing factors such as temperature, pH and time. Quality control of the radiolabeled compound was performed. The radiolabeling yield was found to be 97%. The 99mTc(CO)3 -GCV complex also displayed good in vitro stability during the 24 h period. In vitro cell uptake studies showed that the 99mTc(CO)3-GCV complex is highly uptaken in A-549, PC-3, HeLa cell lines according to the control group 99mTc(I)-tricarbonyl core. The knowledge gained from in vivo and in vitro studies of 99mTc(CO)3-GCV could contribute to the development of a new HSV1-tk gene imaging agent. © by Oldenbourg Wissenschaftsverlag, München.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Management Unit: 2010NBE006en_US
dc.description.sponsorshipAcknowledgment. This study was financially supported by the Ege University Scientific Research Project numbered 2010NBE006 (Bornova Izmir, Turkey). --en_US
dc.identifier.doi10.1524/ract.2013.2003
dc.identifier.endpage128en_US
dc.identifier.issn0033-8230
dc.identifier.issn0033-8230en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage123en_US
dc.identifier.urihttps://doi.org/10.1524/ract.2013.2003
dc.identifier.urihttps://hdl.handle.net/11454/26513
dc.identifier.volume101en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofRadiochimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThymidine kinase enzyme selective imaging radiopharmaceutical: 99mTc(CO)3-Gancicloviren_US
dc.typeArticleen_US

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