Synthesis, radiolabeling and in vivo biodistribution of diethylstilbestrol phosphate derivative (DES-P)

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dc.contributor.authorÜnak P.
dc.contributor.authorBiber Müftüler F.Z.
dc.contributor.authorIçhedef Ç.
dc.contributor.authorMedine E.I.
dc.contributor.authorÖzmen K.
dc.contributor.authorÜnak T.
dc.contributor.authorKilçar A.Y.
dc.contributor.authorGümüşer F.G.
dc.contributor.authorParlak Y.
dc.contributor.authorBilgin E.S.
dc.date.accessioned2019-10-26T21:47:34Z
dc.date.available2019-10-26T21:47:34Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractDiethylstilbestrol (DES) is a well known, nonsteroidal estrogen with high affinity for the estrogen receptor (ER). Today DES is used to treat breast and prostate cancers. A phosphate derivative of DES [Diethylstilbestrol diphosphate (DES-P)] which is specific to tumor cells consisting alkaline phosphatase enzyme was synthesized and labeled with 99mTc using tin chloride as reducing agent. In vivo biological activity of 99mTc labeled diethylstilbestrol phosphate compound ( 99mTc-DES-P) was examined by biodistribution studies on Wistar Albino rats. Statistical evaluation was performed using SPSS 13 program. The percentage (%) radiolabeling yield of 99mTc-DES-P and quality control studies were done by Thin Layer Radio Chromatography (TLRC). Results showed that, 99mTc-DES-P may be proposed as an imaging agent for ER enriched tumors such as uterus and prostate and their metastases in bones. © 2012 Akadémiai Kiadó.en_US
dc.description.sponsorship2009NBE001en_US
dc.description.sponsorshipAcknowledgments The authors thank the financial support from Ege University Scientific Research Fund with the Project Number 2009NBE001. Authors thank to Dr. Memduh Bülbül for providing ALP. --en_US
dc.identifier.doi10.1007/s10967-012-1755-5
dc.identifier.endpage66en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-012-1755-5
dc.identifier.urihttps://hdl.handle.net/11454/18614
dc.identifier.volume293en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject99mTc labeled diethylstilbestrol diphosphate ( 99mTc-DES-P)en_US
dc.subject99mTc-DES-P for receptor saturated studies ( 99mTc-Rec-DES-P)en_US
dc.subjectCancer imagingen_US
dc.subjectDiethylstilbestrol (DES)en_US
dc.titleSynthesis, radiolabeling and in vivo biodistribution of diethylstilbestrol phosphate derivative (DES-P)en_US
dc.typeArticleen_US

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