Microbial transformation of Astragalus sapogenins using Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552

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dc.contributor.authorBedir, Erdal
dc.contributor.authorKula, Ceyda
dc.contributor.authorOner, Ozlem
dc.contributor.authorAltas, Melis
dc.contributor.authorTag, Ozgur
dc.contributor.authorOngen, Gaye
dc.date.accessioned2019-10-27T23:00:49Z
dc.date.available2019-10-27T23:00:49Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractThe microbial transformation of Astragalus sp. derived sapogenins, namely cycloastragenol, astragenol and cyclocanthogenol, by Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552 were investigated. The unique enzyme system of both fungi resulted hydroxylation, cyclization, dehydrogenation and oxidation reactions. Structures of the new metabolites were elucidated by 1-D (H-1, C-13, NOESY), 2-D NMR (DQF-COSY, HMBC, HMQC, NOESY) and HR-MS analyses. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109S345]; European Cooperation in Science and Technology (COST, Action)European Cooperation in Science and Technology (COST) [CM0804]en_US
dc.description.sponsorshipThis work is supported by The Scientific and Technological Research Council of Turkey (TUBITAK, Project No: 109S345) and European Cooperation in Science and Technology (COST, Action No: CM0804). The fungi, Cunninghamella blakesleeana NRRL 1369 was obtained from the ARS Culture Collection, USA, and Glomerealla fusarioides ATCC 9552 was obtained from LGC Standards-ATCC Culture Collection. Finally, we are very greatful to Biological Mass Spectrometry and Proteomics Facility, Izmir Institute of Technology, Department of Chemistry for obtaining mass spectra.en_US
dc.identifier.doi10.1016/j.molcatb.2015.01.013
dc.identifier.endpage34en_US
dc.identifier.issn1381-1177
dc.identifier.issn1873-3158
dc.identifier.issn1381-1177en_US
dc.identifier.issn1873-3158en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1016/j.molcatb.2015.01.013
dc.identifier.urihttps://hdl.handle.net/11454/52066
dc.identifier.volume115en_US
dc.identifier.wosWOS:000353599300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Molecular Catalysis B-Enzymaticen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAstragalusen_US
dc.subjectMicrobial transformationen_US
dc.subjectCycloastragenolen_US
dc.subjectCyclocanthogenolen_US
dc.subjectAstragenolen_US
dc.titleMicrobial transformation of Astragalus sapogenins using Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552en_US
dc.typeArticleen_US

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