A preliminary investigation on the estimation of the sustained-release of indomethacin from agar beads part I

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dc.contributor.authorKirilmaz L.
dc.contributor.authorSahin A.
dc.contributor.authorSarcin Z.
dc.contributor.authorTaneri F.
dc.date.accessioned2019-10-27T00:32:14Z
dc.date.available2019-10-27T00:32:14Z
dc.date.issued1997
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study agar beads containing indomethacin were prepared at different polymer-drug ratios. It was found that the release rate of indomethacin from agar beads was inversely related to the drug content. Lactose was added to the formulations in order to investigate its effect on the release of indomethacin from agar beads. Lactose increased the release rate of indomethacin and in vitro release studies exhibited a ?t dependence indicating a diffusion controlled process from a matrix formulation. All of the prepared formulations gave prolonged release. The release profiles of the formulations were compared with Indocid-R available in the market. The release criteria of all the formulations and Indocid-R were examined according to USP criteria given for indomethacin and general release criteria. At the end of the study, the obtained data were evaluated mathematically. Two equations to be used in the preparation of agar-indomethacin beads with or without lactose for optimum formulation were estimated. It was found that the estimated equations were in good agreement with the observed release results. In addition, in this study the in vivo distribution of agar beads prepared with barium sulfate as a contrast substance in the gastro-intestinal tract was also examined.en_US
dc.identifier.endpage132en_US
dc.identifier.issn1010-0849
dc.identifier.issn1010-0849en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://hdl.handle.net/11454/23723
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofActa Pharmaceutica Turcicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgar beadsen_US
dc.subjectDissolution testen_US
dc.subjectFormulation optimisationen_US
dc.subjectIn vivo distributionen_US
dc.subjectIndomethacinen_US
dc.subjectSustained-releaseen_US
dc.titleA preliminary investigation on the estimation of the sustained-release of indomethacin from agar beads part Ien_US
dc.typeArticleen_US

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