Prevention of anterior scar formation following discectomy with a medishield adhesion barrier: Randomized experimental trial Herniation

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dc.contributor.authorSucu H.K.
dc.contributor.authorSevin I.E.
dc.contributor.authorRezanko T.
dc.contributor.authorHamdi B.
dc.contributor.authorSevin G.
dc.date.accessioned2019-10-27T08:24:13Z
dc.date.available2019-10-27T08:24:13Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractAIM: To investigate whether carboxymethylcellulose/polyethylene oxide (CMC/PEO) gel has a protective effect against epidural scar formation anterior to the dura following discectomy. Ma terIal and Methods: A barrier gel comprised of CMC and PEO (MediShield) was studied as a material to reduce anterior epidural scar formation in a rabbit laminotomy and discectomy model. After laminotomy and disc puncture, the surgical side was either treated with MediShield or used as a surgical control, as determined by random allocation. Two months after surgery, the animals were euthanized, and their lumbar spines were removed in an en bloc excision for pathological evaluation. Scar formation was evaluated as present or absent. Results: The MediShield group contained 12 rabbits, and the control group contained 7 rabbits. Epidural fibrosis was observed in two out of twelve specimens (17%) in the MediShield group and in three of seven (43%) cases in the control group (P=0.305, Fisher's Exact Test). ConclusIon: Though it was not statistically significant, we observed a difference between the MediShield and control group that favored the MediShield group. The application of the CMC/PEO gel might protect against epidural fibrosis after lumbar discectomy, but its efficacy needs to be investigated in larger experimental trials.en_US
dc.identifier.doi10.5137/1019-5149.JTN.6467-12.2
dc.identifier.endpage322en_US
dc.identifier.issn1019-5149
dc.identifier.issn1019-5149en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.6467-12.2
dc.identifier.urihttps://hdl.handle.net/11454/26547
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Societyen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdhesionsen_US
dc.subjectDiscectomyen_US
dc.subjectEpiduralen_US
dc.subjectFibrosisen_US
dc.subjectLaminotomyen_US
dc.titlePrevention of anterior scar formation following discectomy with a medishield adhesion barrier: Randomized experimental trial Herniationen_US
dc.typeArticleen_US

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