Fluorescent micellar nanoparticles by self-assembly of amphiphilic, nonionic and water self-dispersible polythiophenes with "hairy rod" architecture

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dc.contributor.authorCianga, Luminita
dc.contributor.authorBendrea, Anca-Dana
dc.contributor.authorFifere, Nicusor
dc.contributor.authorNita, Loredana Elena
dc.contributor.authorDoroftei, Florica
dc.contributor.authorAg, Didem
dc.contributor.authorSeleci, Muharrem
dc.contributor.authorTimur, Suna
dc.contributor.authorCianga, Ioan
dc.date.accessioned2019-10-27T22:05:36Z
dc.date.available2019-10-27T22:05:36Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractPolymers with "hairy-rod" architecture having oligo/polythiophene (PTh) as main chain and poly (ethylene glycol) (PEG) (M-n = 2000) as flexible side chains were obtained by combining the "macromonomer technique" with specific methods for the synthesis of conjugated polymers. Fluorescent nanoparticles of core-shell type with high colloidal stability were obtained from these water self-dispersible materials by a direct dissolution method in aqueous media. It has been shown that the size and photophysical properties of the micellar nanoparticles in aqueous dispersions as well as the bulk properties of the investigated materials can be tuned by varying the PEG side chain density and by the modality of PEG connection to the PTh main chains. The presence of the PEG shells in the structure of these fluorescent nanoparticles cans suppress the non-specific interactions with biomolecules on the one side and on the other side they work as a biomimetic interface that could facilitate their potential use as cell-imaging agents. The present attempt offers an ease of access alternative to conducting polymer nanoparticle encapsulation in a biocompatible matrix by nanoprecipitation.en_US
dc.description.sponsorshipEuropean Social Fund "Cristofor I. Simionescu" Postdoctoral Fellowship Programme [POSDRU/89/1.5/S/55216]; Sectorial Operational Programme Human Resources Developmenten_US
dc.description.sponsorshipThis paper is dedicated to the 65th anniversary of "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania. One of the authors (A. D. B.) acknowledges the financial support given by European Social Fund "Cristofor I. Simionescu" Postdoctoral Fellowship Programme (ID POSDRU/89/1.5/S/55216), Sectorial Operational Programme Human Resources Development 2007-2013. We are grateful to Dr Luminita Marin from "Petru Poni" Institute of Macromolecular Chemistry, for her kindness regarding polarized optical microscopy investigations and for fruitful discussion. The authors are also grateful to Dr Mariana Pinteala, the head of Centre of Advanced Research in Bionanoconjugates and Biopolymers, at "Petru Poni" Institute of Macromolecular Chemistry, for allowing access to some equipment for materials characterization. We also gratefully acknowledge to R. Bongartz at the Institute for Technical Chemistry at the Leibniz University of Hannover, Germany for her support in cells microscopy studies. The authors thank to Dr Demet Goen-Colak from Istanbul Technical University-Turkey for critically reading the manuscript.en_US
dc.identifier.doi10.1039/c4ra10734a
dc.identifier.endpage56405en_US
dc.identifier.issn2046-2069
dc.identifier.issn2046-2069en_US
dc.identifier.issue99en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage56385en_US
dc.identifier.urihttps://doi.org/10.1039/c4ra10734a
dc.identifier.urihttps://hdl.handle.net/11454/48514
dc.identifier.volume4en_US
dc.identifier.wosWOS:000344997800085en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofRsc Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleFluorescent micellar nanoparticles by self-assembly of amphiphilic, nonionic and water self-dispersible polythiophenes with "hairy rod" architectureen_US
dc.typeArticleen_US

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