Bioreactors in tissue engineering: mimicking the microenvironment

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dc.authorscopusid56305170300
dc.authorscopusid57202507487
dc.authorscopusid57205335558
dc.authorscopusid8394019800
dc.authorscopusid8394019800
dc.contributor.authorBayir E.
dc.contributor.authorSahinler M.
dc.contributor.authorCeltikoglu M.M.
dc.contributor.authorSendemir A.
dc.contributor.authorSendemir A.
dc.date.accessioned2023-01-12T20:22:30Z
dc.date.available2023-01-12T20:22:30Z
dc.date.issued2020
dc.departmentN/A/Departmenten_US
dc.description.abstractOne of the main challenges that have kept tissue-engineered constructs from being widely adopted to clinics is poor cell survival due to limited mass transfer of oxygen and nutrients in thick, clinically relevant sizes of constructs. Tissue engineering bioreactors have been developed to overcome this mass transfer problem, introducing convection as well as diffusion in three-dimensional culture systems. They also provide highly controlled microenvironments for viability, repeatability, and standardization. This microenvironment can mimic the physiological niche, so that functional tissue maturation can be achieved. In this chapter the properties of different types of bioreactors that are commonly used for tissue engineering (TE) applications are examined. This chapter summarizes the main types of bioreactors used for TE, focusing on their design parameters and comparing their main prominences for particular applications. © 2020 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-08-102906-0.00018-0
dc.identifier.endpage752en_US
dc.identifier.isbn9780081029060; 9780081029077
dc.identifier.scopus2-s2.0-85133569790en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage709en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-08-102906-0.00018-0
dc.identifier.urihttps://hdl.handle.net/11454/79480
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBiomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospectsen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3D cultureen_US
dc.subjectbioreactorsen_US
dc.subjectmechanotransductionen_US
dc.subjectperfusionen_US
dc.subjectTissue engineeringen_US
dc.titleBioreactors in tissue engineering: mimicking the microenvironmenten_US
dc.typeBook Chapteren_US

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