Synthesis and voltammetric detection of 1H-benzimidazole derivatives on the interaction with DNA [1H-Benzimidazol türevlerinin sentezi ve DNA ile etkileşimlerinin voltametrik tayini]
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, synthesis and determination of interaction between DNA and 1H-benzimidazole derivatives has been performed by using electrochemical genosensor technology. Detection of DNA - drug interaction mechanism relies on monitoring Differential pulse voltammetric (DPV) responses of drugs at disposable graphite electrodes (DGEs). Interaction of 7 different benzimidazole derivates between double-stranded (ds) and singlestranded (ss) DNA were observed by changing the voltammetric signals of drugs at the detection limits of 0.62 nM of compound 1, 1.23 nM of 2, 1.26 nM of 3, 1.08 nM of 4, 1.13 nM of 5, 0.69 nM of 6 and 0.42 nM of 7, respectively.
Açıklama
Anahtar Kelimeler
1H-benzimidazole, DNA-drug interaction, Electrochemical genosensor, Synthesis
Kaynak
Marmara Pharmaceutical Journal
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
16
Sayı
1
