The effects of cholesterol lowering therapy with atorvastatin on flow-mediated vasodilation in patients with hypercholesterolemic coronary artery disease

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dc.contributor.authorErcan E.
dc.contributor.authorCeyhan C.
dc.contributor.authorGürgün C.
dc.contributor.authorTekten T.
dc.contributor.authorOnbasi A.
dc.contributor.authorZoghi M.
dc.contributor.authorTürkoglu C.
dc.date.accessioned2019-10-27T00:25:19Z
dc.date.available2019-10-27T00:25:19Z
dc.date.issued2001
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground. Hypercholesterolemia impairs the endothelial function. Lipid-lowering therapy has been reported to improve endothelial function. Aim. To assess the effects of atorvastatin on endothelial function by the measurement of flow-mediated vasodilatation (FMD) in patients with hypercholesterolemia and coronary artery disease (CAD). Methods. In twenty-six patients (mean age 55±5 years) with angiographically proven CAD a high-resolution vascular ultrasound was used at baseline and after two months of atorvastatin therapy (10 mg/day) in order to measure brachial artery responses to reactive hyperaemia and sublingual nitrate (endothelium-independent mechanism). The baseline FMD values obtained in patients were compared with those measured in healthy controls. Results. The FMD values in the control group were significantly higher than in the CAD group (12.5±6% versus 3.8±3%, p<0.001). The FMD improved significantly in CAD patients after the effective lowering of total cholesterol and LDL-cholesterol by atorvastatin therapy (3.8±3% versus 7.2±3.5%, p<0.001) whereas no significant change in the endothelium-independent vasodilation was noted. Conclusions. Endothelium-dependent vasodilatation of the brachial artery is impaired in CAD patients. Significant lowering of cholesterol levels in CAD patients with atorvastatin markedly improves endothelium-dependent arterial vasodilatation.en_US
dc.identifier.endpage506en_US
dc.identifier.issn0022-9032
dc.identifier.issn0022-9032en_US
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage503en_US
dc.identifier.urihttps://hdl.handle.net/11454/23227
dc.identifier.volume55en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKlinika Kardiologii CMKPen_US
dc.relation.ispartofKardiologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectEndotheliumen_US
dc.subjectStatinsen_US
dc.subjectVasodilationen_US
dc.titleThe effects of cholesterol lowering therapy with atorvastatin on flow-mediated vasodilation in patients with hypercholesterolemic coronary artery diseaseen_US
dc.typeArticleen_US

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