99mTc-glucoheptonate-guanine: Synthesis, biodistribution and imaging in animals

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dc.contributor.authorUnak P.
dc.contributor.authorTeksoz S.
dc.contributor.authorBiber Muftuler F.Z.
dc.contributor.authorMedine E.I.
dc.contributor.authorAcar C.
dc.contributor.authorYurekli Y.
dc.date.accessioned2019-10-27T08:36:46Z
dc.date.available2019-10-27T08:36:46Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of the current study was to design a nucleotide-based radiopharmaceutical which could be labeled with 99mTc and to investigate its radiopharmaceutical efficiency and stability. GHA (glucoheptonate) was used as bifunctional chelate. GHA was labeled with 99mTc by SnCl2 reduction method first, and then G (guanine) was conjugated with 99mTc-GHA at 90°C. In order to determine its radiopharmaceutical stability, thin layer radio chromatography (TLRC) and electrophoresis were employed. In addition, the results were confirmed using high performance liquid radio chromatography (HPLRC). Scintigraphic imaging was performed on rats with mammary tumors, while tissue distribution was determined on Albino Wistar rats. Labeling yield was found to be over 95% and the labeled complex maintained its stability during the study period. The lipophilicity of the 99mTc-GHG was measured and the partition coefficient (logP) of the labeled compound calculated. The results demonstrated that the uptake of 99mTc-GHG (99mTc- glucoheptonate-guanine) reached its maximum at 3 hours p.i. in stomach and intestines. Main way of excretion was renal. Hepatobiliary excretion was also observed. In conclusion, 99mTc-GHG may be useful as a nucleotide-based radiopharmaceutical for in vivo applications. © 2008 Springer Science+Business Media, LLC.en_US
dc.description.sponsorshipThe authors thank for the financial support from Ege University Scientific Research Fund. --en_US
dc.identifier.doi10.1007/s10967-007-6934-4
dc.identifier.endpage385en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-007-6934-4
dc.identifier.urihttps://hdl.handle.net/11454/27436
dc.identifier.volume275en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.title99mTc-glucoheptonate-guanine: Synthesis, biodistribution and imaging in animalsen_US
dc.typeArticleen_US

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