Carbon Nanotubes Modified Graphite Electrodes for Monitoring of Biointeraction Between 6-Thioguanine and DNA

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dc.contributor.authorUnal, Didem Nur
dc.contributor.authorEksin, Ece
dc.contributor.authorErdem, Arzum
dc.date.accessioned2019-10-27T11:05:12Z
dc.date.available2019-10-27T11:05:12Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this present study, single-walled carbon nanotubes (SWCNT) modified disposable pencil graphite electrodes (SWCNT-PGEs) were developed for the electrochemical monitoring of anticancer drug, and its interaction with double stranded DNA (dsDNA). Under this aim, SWCNT-PGEs were applied for the first time in the literature to analyse of 6-Thioguanine (6-TG), and also to investigate its interaction with DNA by voltammetric and impedimetric methods. The surface morphologies of PGE and SWCNT-PGE were explored using scanning electron microscopy (SEM) and electrochemical characterization of unmodified/modified electrodes was performed by cyclic voltammetry (CV). Experimental parameters; such as, the concentration of 6-TG and its interaction time with dsDNA were optimized by using differential pulse voltammetry (DPV). Additionally, the interaction of 6-TG with dsDNA was studied in case of different interaction times by electrochemical impedance spectroscopy (EIS) in contrast to voltammetric results. The detection limit of 6-TG was found to be 0.25 mu M by SWCNT-PGE.en_US
dc.description.sponsorshipTurkish Academy of Sciences (TUBA)Turkish Academy of Sciencesen_US
dc.description.sponsorshipA.E would like to express her gratitude to the Turkish Academy of Sciences (TUBA) as a Principal member for its partial support.en_US
dc.identifier.doi10.1002/elan.201700270
dc.identifier.endpage2299en_US
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.issn1040-0397en_US
dc.identifier.issn1521-4109en_US
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2292en_US
dc.identifier.urihttps://doi.org/10.1002/elan.201700270
dc.identifier.urihttps://hdl.handle.net/11454/31626
dc.identifier.volume29en_US
dc.identifier.wosWOS:000412547200016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofElectroanalysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbon nanotubesen_US
dc.subjectpencil graphite electrodesen_US
dc.subjectdrug-DNA interactionen_US
dc.subject6-Thioguanineen_US
dc.subjectelectrochemical biosensoren_US
dc.titleCarbon Nanotubes Modified Graphite Electrodes for Monitoring of Biointeraction Between 6-Thioguanine and DNAen_US
dc.typeArticleen_US

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