The impact of hereditary angioedema on quality of life and family planning decisions

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dc.contributor.authorTuncel, Ozlem Kuman
dc.contributor.authorGokmen, Nihal Mete
dc.contributor.authorDemur, Ece
dc.contributor.authorGulbahar, Okan
dc.contributor.authorPirildar, Sebnem
dc.date.accessioned2019-10-27T09:41:00Z
dc.date.available2019-10-27T09:41:00Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective Hereditary angioedema is a serious disease with unpredictable attacks. It has an impact on patients' health-related quality of life. This study aimed to assess the quality of life of the hereditary angioedema patients and to investigate the relationship between quality of life and demographic, clinical, laboratory, and psychiatric parameters. Method A semistructured face-to-face interview, Hamilton depression rating scale, and Hamilton anxiety rating scale were performed by a psychiatrist. Participants completed Medical Outcomes Study Short Form-36, Revised Form of the Multidimensional Scale of Perceived Social Support, Anxiety Sensitivity Index-3, and Adult Separation Anxiety Questionnaire. Patients' complement results were recorded, and clinical data obtained by interview were cross-checked from patients' files. Results In 33 hereditary angioedema patients, subscales of the Study Short Form-36, except for physical functioning, vitality, and mental health were significantly lower compared with population norms. Quality of life scores were found to be correlated with depression, anxiety, anxiety sensitivity, separation anxiety, perceived social support, perceived discrimination, perceived limitation, treatment naive C1-Inhibitor function, and C1q level. Physical role functioning scores were better in the patients using attenuated androgens (p = 0.006, t = -3.027). Hereditary angioedema contributed to the marital problems and childbearing decisions of the patients. Conclusion Hereditary angioedema results in significant impairment in quality of life of the patients and has an impact on family life and life style of the patients. In case of depressive and/or anxiety symptoms, patients should be referred to psychiatrists for better quality of life. Higher levels of C1-inhibitor function and C1q seem to correlate with better quality of life; these needs to be further studied.en_US
dc.identifier.doi10.1177/0091217419837068
dc.identifier.endpage394en_US
dc.identifier.issn0091-2174
dc.identifier.issn1541-3527
dc.identifier.issn0091-2174en_US
dc.identifier.issn1541-3527en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage377en_US
dc.identifier.urihttps://doi.org/10.1177/0091217419837068
dc.identifier.urihttps://hdl.handle.net/11454/28561
dc.identifier.volume54en_US
dc.identifier.wosWOS:000486236600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofInternational Journal of Psychiatry in Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthereditary angioedemaen_US
dc.subjectmedical illnessen_US
dc.subjectquality of lifeen_US
dc.subjectdepressionen_US
dc.subjectfamily planningen_US
dc.subjectanxiety sensitivityen_US
dc.subjectC1-inhibitor function levelen_US
dc.subjectmarriageen_US
dc.subjectbiopsychosocialen_US
dc.subjectcomorbidityen_US
dc.titleThe impact of hereditary angioedema on quality of life and family planning decisionsen_US
dc.typeArticleen_US

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