Vestibular impairment in Charcot–Marie–Tooth disease

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dc.contributor.authorAkdal, G.
dc.contributor.authorKoçoğlu, K.
dc.contributor.authorTanrıverdizade, T.
dc.contributor.authorBora, E.
dc.contributor.authorBademkıran, F.
dc.contributor.authorYüceyar, A.N.
dc.contributor.authorKarasoy, H.
dc.date.accessioned2020-12-01T11:52:58Z
dc.date.available2020-12-01T11:52:58Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To find out if Charcot–Marie–Tooth (CMT) patients, who have peripheral vestibular as well as peripheral somatosensory impairment, have worse postural balance than those who do not. Methods: We studied 32 patients with various CMT phenotypes and genotypes. Vestibular function was measured with the video head impulse test (vHIT) which tests vestibulo-ocular reflex (VOR) gain from each of the six semicircular canals in response to rapid head rotations. Postural balance was evaluated with a battery of four postural tests with emphasis on the modified clinical test of sensory integration in balance (mCTSIB). Results: Half of the 32 patients had some impairment of vestibular function ranging from mild, affecting only 1–2 semicircular canals, to almost total affecting all 6 semicircular canals. Their mCTSIB scores correlated with VOR gain from the vertical rather than from the lateral semicircular canals. The worse the vertical VOR gain the worse the mCTSIB score. Conclusion: We propose that any CMT patient could have clinically inapparent vestibular impairment that can be easily measured with the vHIT. This vestibular impairment could be contributing to their imbalance and could respond to a focused vestibular rehabilitation program. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.en_US
dc.description.sponsorship216S658 Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAKen_US
dc.description.sponsorshipStudy funded by the Scientific and Technological Research Council of Turkey (TÜBİTAK) under Grant no. (216S658). Acknowledgementsen_US
dc.identifier.doi10.1007/s00415-020-10186-x
dc.identifier.issn0340-5354
dc.identifier.issn0340-5354en_US
dc.identifier.pmid32862243en_US
dc.identifier.scopus2-s2.0-85089964652en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00415-020-10186-x
dc.identifier.urihttps://hdl.handle.net/11454/61700
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCMT diseaseen_US
dc.subjectModified clinical test of sensory integration in balanceen_US
dc.subjectVestibulo-ocular reflexen_US
dc.subjectVideo head impulse testen_US
dc.titleVestibular impairment in Charcot–Marie–Tooth diseaseen_US
dc.typeArticleen_US

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