The comparison of the effects of hormone replacement therapy with the combination of pulsed estrogen-medroxyprogesterone acetate and the conjugated estrogen-medroxyprogesterone acetate on vosomotor complaints and uterine bleeding patterns in physiologic postmenopausal patients [Dogal menopozda olan olgularda pulse östrojen- medroksiprogesteron asetat kombinasyonu ve konjuge östrojen- medroksiprogesteron asetat i·le yapilan hormon replasman tedavilerinin vazomotor yakinmalara ve uterin kanamalara olan etkilerinin karş ilaştirilmasi]

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dc.contributor.authorÖzşener S.
dc.contributor.authorAkercan F.
dc.contributor.authorÇirpan T.
dc.contributor.authorCoşan Terek M.
dc.contributor.authorItil I.M.
dc.contributor.authorYücebilgin S.
dc.date.accessioned2019-10-27T00:10:46Z
dc.date.available2019-10-27T00:10:46Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: The comparison of the effects of hormone replacement therapy with pulse estrogen-medroxyprogesterone acetate and conjugated estrogene-medroxyprogesterone acetate on vasomotor complaints and uterine bleeding patterns in physiologic postmenopausal patients. STUDY DESIGN: Total 80 cases who were admitted to Ege University Medical Faculty Gynecology Department's Menopause Clinic between January 2002-January 2004 and using these regimens were included for this retrospective study. The hormone replacement therapy preperations which were the subject of this study were: the combination of estradiol hemihydrate (aerodiol, 150 meg, Servier) and medroxyprogesterone acetate (Farlutal, 5 mg, Deva) as pulsed estrogen-MPA and estrogen 0,625 mg and medroxyprogesterone acetate 5 mg (Premelle Cycle, Wyeth) as conjugated estrogen-MPA combination. There were 30 cases in pulsed estrogen-MPA group and 50 patients in conjugated estrogen-MPA group. RESULTS: The average age of the patients was 50.912.5 years. There were no significant difference between the age, menopausal age, body-mass index (BMI) and postmenopausal period of the groups (p>0.05). There were no significant difference in hot flush frequencies (average 8.60±3.23) (p>0.05). Kupperman index values on initial, third and sixth months were 27.3±4.8; 10.2±2.9; 9.5±2.7 in pulsed estrogene-MPA group and 7.9±5.9; 10.5±2.3 ve 10.2±2.1 in conjugated estrogen-MPA group and no significant difference were found between the groups (p>0.05). The withdrawal bleeding was seen more frequently in oral conjugated estrogen-MPA group. But the difference was not significant (p=0.061). In the same way, the irregular bleeding (every bleeding pattern except withdrawal bleeding) episodes were seen in conjugated estrogen-MPA group more than the other group but, the difference was not significant (p=0.426). CONCLUSION: The efficacy and tolerability of pulse estrogene-MPA therapy in physiological postmenopausal patients was similar to oral conjugated estrogene-MPA therapy and could be used as an effective therapeutic choice.en_US
dc.identifier.endpage84en_US
dc.identifier.issn1016-5126
dc.identifier.issn1016-5126en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://hdl.handle.net/11454/22042
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofJinekoloji ve Obstetrik Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConjugated Estrogenen_US
dc.subjectMedroxyprogesterone Acetateen_US
dc.subjectPulsed Estrogenen_US
dc.titleThe comparison of the effects of hormone replacement therapy with the combination of pulsed estrogen-medroxyprogesterone acetate and the conjugated estrogen-medroxyprogesterone acetate on vosomotor complaints and uterine bleeding patterns in physiologic postmenopausal patients [Dogal menopozda olan olgularda pulse östrojen- medroksiprogesteron asetat kombinasyonu ve konjuge östrojen- medroksiprogesteron asetat i·le yapilan hormon replasman tedavilerinin vazomotor yakinmalara ve uterin kanamalara olan etkilerinin karş ilaştirilmasi]en_US
dc.typeArticleen_US

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