Discovery of a Uracil-Derived Small Organic Ligand with Cytotoxic Effect on Human PC-3 Cell Lines via Apoptosis

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dc.contributor.authorPoslu, Ayse Halic
dc.contributor.authorBalaban, Rumeysa
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorErtik, Onur
dc.contributor.authorCecener, Gulsah
dc.contributor.authorKoz, Omer
dc.contributor.authorKoz, Gamze
dc.date.accessioned2025-05-08T12:59:12Z
dc.date.available2025-05-08T12:59:12Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.description.abstractA series of novel 6-amino-5-salicylidene uracils (1-19) were efficiently synthesized from the condensation reaction of 5,6-diamino-1,3-dimethyluracil with substituted salicylaldehydes. The structural characterization of the compounds was performed with spectroscopic methods and elemental analysis. All compounds were evaluated for their in vitro cytotoxic activity against PC-3 (human prostate adenocarcinoma), A549 (human alveolar adenocarcinoma) and SHSY-5Y (human neuroblastoma) cancer cell lines. 3,5-di-tert-Butylsalicylaldehyde derived salicylideneuracil (6ASU-8) showed promising cytotoxic activity against PC-3 cells with an IC50 value of 1.53 +/- 1.01 mu M, compared to doxorubicin, which had an IC50 value of 3.77 +/- 1.34 mu M. 6ASU-8 induced cell cycle arrest at the G2/M phase and promoted apoptosis in PC-3 cells (p<0.05*). Molecular docking results supported the experimental data, indicating that 6ASU-8 is more effective than doxorubicin. Additionally, in silico ADME analysis revealed that 6ASU-8 possesses acceptable predictive physicochemical properties.
dc.identifier.citationPoslu, A. H., Balaban, R., Nalbantsoy, A., Ertik, O., Çeçener, G., Koz, Ö., & Koz, G. (2024). Discovery of a Uracil‐Derived small organic ligand with cytotoxic effect on human PC‐3 cell lines via apoptosis. ChemistrySelect (Weinheim), 9(36), n/a.
dc.identifier.doi10.1002/slct.202403713
dc.identifier.endpage9
dc.identifier.issn23656549
dc.identifier.issue36
dc.identifier.scopus2-s2.0-8520472413
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1002/slct.202403713
dc.identifier.urihttps://hdl.handle.net/11454/117223
dc.identifier.volume9
dc.identifier.wosWOS:001318769800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorNalbantsoy, Ayse
dc.language.isoen
dc.publisherWiley - VCH Verlag Gmbh
dc.relation.ispartofChemistrySelect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectCytotoxicity
dc.subjectMolecular docking
dc.subjectPC-3
dc.subjectUracil
dc.titleDiscovery of a Uracil-Derived Small Organic Ligand with Cytotoxic Effect on Human PC-3 Cell Lines via Apoptosis
dc.typeArticle

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