Could be radiolabeled flavonoid used to evaluate infection?

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dc.contributor.authorLambrecht F.Y.
dc.contributor.authorYilmaz O.
dc.contributor.authorBayrak E.
dc.contributor.authorKocagozoglu G.
dc.contributor.authorDurkan K.
dc.date.accessioned2019-10-26T22:44:41Z
dc.date.available2019-10-26T22:44:41Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to determine whether [131I]apigenin is a powerful and discrimination infection from inflammation for scintigraphic imaging. The study was carried out in inflamed rats with Staphylococcus aureus (S. aureus) and sterile inflamed rats with turpentine oil. Biodistribution study of [131I]apigenin was performed in the rats. Apigenin was labeled with 131I by iodogen method. Obtained [131I]apigenin with high yield (98%) was injected i.v. to both group rats. The results were expressed as the percent uptake of injected dose per gram of organ (%ID/g), the bacterial infected and sterile inflamed muscles. Binding of [ 131I]apigenin to the infected thigh muscle (target muscle = T) and normal thigh muscle (non-target muscle = NT) ratio (T/NT = 4.51 at 15 min) was higher than binding to bacterial inflamed muscle (T/NT = 2.25 at 15 min) of rats. [131I]apigenin showed good localization in both inflamed tissues. This uptake in the sterile inflamed tissue is higher than bacterial infected tissue. [131I]apigenin might be useful for imaging of inflamed tissues. However, it is not discriminate sterile inflamed tissue from bacterial infected tissue. © 2009 Akadémiai Kiadó, Budapest, Hungary.en_US
dc.identifier.doi10.1007/s10967-009-0353-7
dc.identifier.endpage506en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage503en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-009-0353-7
dc.identifier.urihttps://hdl.handle.net/11454/20064
dc.identifier.volume283en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[131I]apigeninen_US
dc.subjectApigeninen_US
dc.subjectImagingen_US
dc.subjectInflamed raten_US
dc.subjectS. aureusen_US
dc.titleCould be radiolabeled flavonoid used to evaluate infection?en_US
dc.typeArticleen_US

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